INT302816

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Context Info
Confidence 0.36
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.90
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spleen 1
Ubb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 64 88.72 High High
Inflammation 43 88.32 High High
withdrawal 1 78.36 Quite High
rheumatoid arthritis 65 5.00 Very Low Very Low Very Low
cytokine 15 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 45 99.80 Very High Very High Very High
Necrosis 5 99.30 Very High Very High Very High
Cancer 12 99.12 Very High Very High Very High
Arthritis 62 88.72 High High
Infection 1 77.40 Quite High
INFLAMMATION 17 73.32 Quite High
Disease 3 65.56 Quite High
Rheumatoid Arthritis 65 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Juvenile Chronic Polyarthritis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Over the past few years, sphingosine-1-phosphate, interleukin-7 receptor, spleen tyrosine kinase, extracellular signal-regulated kinase, mitogen-activated protein kinase 5/p38 kinase regulated/activated protein kinase, micro-RNAs, tumor necrosis factor-related apoptosis inducing ligand and the polyubiquitin-proteasome pathway were identified as promising novel targets for potential antiarthritis drug development.
polyubiquitin Binding (ligand) of in spleen associated with necrosis, cancer and apoptosis
1) Confidence 0.36 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2842969 Disease Relevance 0.90 Pain Relevance 0.39

General Comments

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