INT302824

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Context Info
Confidence 0.11
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.64
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Mapkapk5, Hspb2) response to stress (Mapkapk5, Hspb2) cytoplasm (Mapkapk5, Hspb2)
kinase activity (Mapkapk5)
Anatomy Link Frequency
monocyte 2
Mapkapk5 (Mus musculus)
Hspb2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 15 96.20 Very High Very High Very High
Inflammatory response 3 96.08 Very High Very High Very High
rheumatoid arthritis 65 89.24 High High
methotrexate 4 74.40 Quite High
Arthritis 64 71.96 Quite High
Inflammation 43 71.56 Quite High
agonist 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 1 100.00 Very High Very High Very High
INFLAMMATION 17 96.08 Very High Very High Very High
Apoptosis 45 93.36 High High
Rheumatoid Arthritis 65 89.24 High High
Arthritis 62 71.96 Quite High
Pressure And Volume Under Development 1 33.52 Quite Low
Hyperplasia 2 27.20 Quite Low
Malignant Neoplastic Disease 1 12.40 Low Low
Cancer 12 5.00 Very Low Very Low Very Low
Necrosis 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Once activated, MK5/PRAK was reported to directly phosphorylate heat shock protein 27 (Hsp27) [91, 92], the latter having been implicated in several physiologically relevant immune-mediated inflammatory responses such as CD8+ lymphocyte subset expansion and apoptosis resistance [93] as well as in the activation of the Toll-like receptor-4 in monocyte-derived RA DCs [94].
PRAK Positive_regulation (phosphorylate) of Phosphorylation (phosphorylate) of Hsp27 in monocyte associated with inflammatory response, shock, rheumatoid arthritis and apoptosis
1) Confidence 0.11 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.64 Pain Relevance 0.40

General Comments

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