INT302825

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Context Info
Confidence 0.00
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.64
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Xpnpep1) peptidase activity (Xpnpep1) mitochondrion (Creb1)
nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)
Creb1 (Mus musculus)
Xpnpep1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 43 97.84 Very High Very High Very High
Arthritis 64 97.32 Very High Very High Very High
methotrexate 4 86.72 High High
rheumatoid arthritis 65 84.28 Quite High
Inflammatory response 3 78.24 Quite High
cytokine 15 66.76 Quite High
agonist 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 62 97.84 Very High Very High Very High
Rheumatoid Arthritis 65 84.28 Quite High
Apoptosis 45 80.44 Quite High
INFLAMMATION 17 77.84 Quite High
Shock 1 72.72 Quite High
Cancer 12 56.80 Quite High
Necrosis 5 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Juvenile Chronic Polyarthritis 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the MK5/PRAK promoters of human, mouse and rat all contain a cyclic AMP (cAMP) responsive element that binds to CREB in vitro [96], indicating that molecules involved in inflammatory arthritis that also activate cAMP-dependent protein kinase A (e.g., PGE2), may also upregulate MK5/PRAK transcription.
CREB Binding (binds) of AMP associated with inflammation and arthritis
1) Confidence 0.00 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.64 Pain Relevance 0.39

General Comments

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