INT302828

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Context Info
Confidence 0.07
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.38
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Mapkapk5, Mapk1) nucleus (Mapkapk5, Mapk1) kinase activity (Mapkapk5, Mapk1)
nucleoplasm (Mapk1) mitochondrion (Mapk1) protein complex (Mapk1)
Mapkapk5 (Mus musculus)
Mapk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 86 97.96 Very High Very High Very High
Arthritis 128 97.44 Very High Very High Very High
methotrexate 8 95.36 Very High Very High Very High
rheumatoid arthritis 130 92.92 High High
Inflammatory response 6 86.88 High High
cytokine 30 75.40 Quite High
agonist 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 124 97.96 Very High Very High Very High
Rheumatoid Arthritis 130 92.92 High High
Apoptosis 90 89.08 High High
INFLAMMATION 34 86.48 High High
Shock 2 81.36 Quite High
Cancer 24 39.52 Quite Low
Pressure And Volume Under Development 2 12.72 Low Low
Hyperplasia 4 6.40 Low Low
Necrosis 10 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MK5/PRAK was also shown to activate atypical ERK 3/4 [95], but the significance of this pathway in inflammatory arthritis remains unclear.
PRAK Positive_regulation (activate) of ERK associated with inflammation and arthritis
1) Confidence 0.07 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.69 Pain Relevance 0.46
MK5/PRAK was also shown to activate atypical ERK 3/4 [95], but the significance of this pathway in inflammatory arthritis remains unclear.
MK5 Positive_regulation (activate) of ERK associated with inflammation and arthritis
2) Confidence 0.03 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.69 Pain Relevance 0.46

General Comments

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