INT302832

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Context Info
Confidence 0.04
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.63
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Akt1) aging (Akt1) enzyme binding (Akt1)
carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)
Tnfsf10 (Mus musculus)
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 65 100.00 Very High Very High Very High
agonist 2 92.92 High High
Inflammation 43 91.64 High High
Arthritis 64 82.72 Quite High
cytokine 15 69.32 Quite High
methotrexate 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 65 100.00 Very High Very High Very High
Cancer 12 96.88 Very High Very High Very High
Apoptosis 45 96.48 Very High Very High Very High
INFLAMMATION 17 91.64 High High
Necrosis 5 85.96 High High
Arthritis 62 82.72 Quite High
Hyperplasia 2 48.32 Quite Low
Repression 1 10.20 Low Low
Death 3 5.00 Very Low Very Low Very Low
Juvenile Chronic Polyarthritis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morel et al. [123] first showed that TRAIL induced RA-SF proliferation through activation of MAPK and PI3K/Akt since RA-SF proliferation could be inhibited by the ERK 1/2 SMI, PD98059, the p38 kinase SMI, SB203580 and the PI3K/Akt SMI, LY294002, respectively.
TRAIL Positive_regulation (activation) of Akt associated with rheumatoid arthritis
1) Confidence 0.04 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 1.63 Pain Relevance 0.56

General Comments

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