INT302839

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Context Info
Confidence 0.15
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.41
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) cell morphogenesis (Bcl2) endoplasmic reticulum (Bcl2)
intracellular (Bcl2) cytoplasm (Bcl2) cell proliferation (Bcl2)
MIR15A (Homo sapiens)
Bcl2 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 64 96.72 Very High Very High Very High
Inflammation 43 87.00 High High
rheumatoid arthritis 65 80.56 Quite High
Osteoarthritis 1 44.80 Quite Low
cytokine 15 30.24 Quite Low
methotrexate 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 62 96.72 Very High Very High Very High
Apoptosis 45 81.60 Quite High
Rheumatoid Arthritis 65 80.56 Quite High
Repression 1 80.40 Quite High
Cancer 12 76.64 Quite High
Necrosis 5 76.16 Quite High
Hyperplasia 2 67.44 Quite High
Osteoarthritis 1 44.80 Quite Low
INFLAMMATION 17 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, the antiapoptotic protein bcl-2 was downregulated by miR-15a whereas caspase-3 was increased by miR15-a in the mice with autoantibody-induced arthritis compared to the control group.
miR-15a Negative_regulation (downregulated) of bcl-2 associated with arthritis
1) Confidence 0.15 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 1.41 Pain Relevance 0.47

General Comments

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