INT302842

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Context Info
Confidence 0.24
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.92
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (S1PR1, S1pr1) signal transducer activity (S1PR1, S1pr1) signal transduction (S1pr1)
cell adhesion (S1PR1)
Anatomy Link Frequency
immune cells 1
lymphoid tissues 1
S1PR1 (Homo sapiens)
S1pr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 128 84.64 Quite High
Inflammation 86 84.24 Quite High
rheumatoid arthritis 130 77.20 Quite High
metalloproteinase 2 39.32 Quite Low
chemokine 4 34.68 Quite Low
cytokine 30 34.20 Quite Low
methotrexate 8 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 124 84.64 Quite High
Apoptosis 90 82.24 Quite High
Rheumatoid Arthritis 130 77.20 Quite High
Necrosis 10 76.24 Quite High
Cancer 24 75.88 Quite High
INFLAMMATION 34 62.12 Quite High
Carcinoma 2 35.44 Quite Low
Adhesions 2 35.08 Quite Low
Disease 6 22.52 Low Low
Death 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the binding of S1P to its receptors, S1PR1/S1PR2 [34], triggers and is required for stimulating the movement of immune cells from the thymus and lymph nodes into lymphatic vessels from where they can travel through peripheral circulation to synovial joints.
S1PR1 Binding (binding) of S1P in immune cells
1) Confidence 0.24 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.51 Pain Relevance 0.15
Thus, inhibiting the formation of S1P either by targeting SphK, or by inhibiting the binding of S1P to S1PR1/S1PR2 is likely to result in a reduced egress of activated T-cell and B-cell from lymphoid tissues and presumably fewer activated lymphocytes making their way into the synovium.
S1PR1 Binding (binding) of S1P in lymphoid tissues
2) Confidence 0.23 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.41 Pain Relevance 0.18

General Comments

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