INT302846

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Context Info
Confidence 0.28
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.41
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (S1PR1, S1pr1) signal transducer activity (S1PR1, S1pr1) signal transduction (S1pr1)
cell adhesion (S1PR1)
Anatomy Link Frequency
lymphoid tissues 2
S1PR1 (Homo sapiens)
S1pr1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 65 77.20 Quite High
Inflammation 43 60.64 Quite High
Arthritis 64 59.60 Quite High
metalloproteinase 1 8.04 Low Low
cytokine 15 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 45 82.84 Quite High
Rheumatoid Arthritis 65 77.20 Quite High
Arthritis 62 60.64 Quite High
Necrosis 5 44.96 Quite Low
Cancer 12 44.60 Quite Low
Carcinoma 1 35.44 Quite Low
INFLAMMATION 17 30.84 Quite Low
Death 3 5.00 Very Low Very Low Very Low
Juvenile Chronic Polyarthritis 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, inhibiting the formation of S1P either by targeting SphK, or by inhibiting the binding of S1P to S1PR1/S1PR2 is likely to result in a reduced egress of activated T-cell and B-cell from lymphoid tissues and presumably fewer activated lymphocytes making their way into the synovium.
Negative_regulation (inhibiting) of S1PR1 Binding (binding) of S1P in lymphoid tissues
1) Confidence 0.28 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.41 Pain Relevance 0.18

General Comments

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