INT302883

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 4.13
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (TXN, Alb) cytoplasm (TXN, Alb) extracellular region (TXN, Alb)
nucleoplasm (TXN) mitochondrion (TXN) small molecule metabolic process (TXN)
Anatomy Link Frequency
plasma 2
TXN (Homo sapiens)
Alb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
palliative 6 73.40 Quite High
peripheral neuropathy 3 51.04 Quite High
Inflammatory response 54 12.72 Low Low
dexamethasone 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diarrhoea 3 99.44 Very High Very High Very High
Vomiting 27 98.88 Very High Very High Very High
Alopecia 9 98.16 Very High Very High Very High
Neutropenia 3 97.76 Very High Very High Very High
Leukopenia 12 97.24 Very High Very High Very High
Anaemia 33 96.76 Very High Very High Very High
Head & Neck Cancer 3 90.24 High High
Malignant Neoplastic Disease 3 88.04 High High
Non-small-cell Lung Cancer 66 83.92 Quite High
Toxicity 84 82.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Albumin binds TXN and transports it in the bloodstream, allowing its gradual liberation, thus decreasing its toxic effects [37].
TXN Binding (binds) of Albumin
1) Confidence 0.06 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2843671 Disease Relevance 1.41 Pain Relevance 0
The binding of TXN to plasma proteins such as albumin is important for achieving its therapeutic target.
TXN Binding (binding) of albumin in plasma
2) Confidence 0.05 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2843671 Disease Relevance 1.51 Pain Relevance 0
TXN is transported by binding with plasma proteins, such as albumin, the latter significant for its pharmacokinetic behavior; it is also extensively protein-bound (95-98%) to tissue proteins [11], and its removal is primarily carried out by hepatic metabolism [12].
TXN Binding (binding) of albumin in plasma
3) Confidence 0.05 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2843671 Disease Relevance 1.21 Pain Relevance 0.10

General Comments

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