INT30293

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Context Info
Confidence 0.36
First Reported 1985
Last Reported 1985
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC)
extracellular space (POMC) generation of precursor metabolites and energy (POMC) signal transduction (POMC)
Anatomy Link Frequency
PMN 2
POMC (Homo sapiens)
IGKV1D-39 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 1 100.00 Very High Very High Very High
Opioid 3 97.74 Very High Very High Very High
narcan 1 69.28 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since reactive oxygen species are crucial to these activities, the affect of opioid peptides on superoxide (O-2) generation was evaluated with the use of lucigenin-enhanced chemiluminesence (CL). beta-Endorphin and dynorphin stimulate the production of O-2 in human polymorphonuclear leukocytes (PMN) and peritoneal macrophages (PMO) at peptide concentrations that prevail systemically (10(-14)-10(-12)M).
beta-Endorphin Positive_regulation (stimulate) of Gene_expression (production) of O-2 in PMN associated with dynorphin and opioid
1) Confidence 0.36 Published 1985 Journal Endocrinology Section Abstract Doc Link 2862014 Disease Relevance 0 Pain Relevance 0.34

General Comments

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