INT30294

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Context Info
Confidence 0.62
First Reported 1985
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 30
Total Number 30
Disease Relevance 8.66
Pain Relevance 5.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
granulocytes 3
neutrophils 3
respiratory 1
IGKV1D-39 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 1 99.70 Very High Very High Very High
Inflammation 513 99.56 Very High Very High Very High
Opioid 4 96.88 Very High Very High Very High
agonist 3 96.72 Very High Very High Very High
imagery 34 95.92 Very High Very High Very High
Enkephalin 27 95.52 Very High Very High Very High
narcan 2 89.96 High High
antagonist 3 89.60 High High
Arthritis 17 89.04 High High
cytokine 51 88.64 High High
Disease Link Frequency Relevance Heat
Sleep Disorders 245 100.00 Very High Very High Very High
INFLAMMATION 618 99.56 Very High Very High Very High
Chronic Disease 1 99.36 Very High Very High Very High
Stress 39 98.04 Very High Very High Very High
Adult Respiratory Distress Syndrome 4 97.76 Very High Very High Very High
Adhesions 697 97.44 Very High Very High Very High
Myocardial Infarction 12 97.36 Very High Very High Very High
Disease 75 96.40 Very High Very High Very High
Injury 18 92.16 High High
Necrosis 34 91.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since reactive oxygen species are crucial to these activities, the affect of opioid peptides on superoxide (O-2) generation was evaluated with the use of lucigenin-enhanced chemiluminesence (CL). beta-Endorphin and dynorphin stimulate the production of O-2 in human polymorphonuclear leukocytes (PMN) and peritoneal macrophages (PMO) at peptide concentrations that prevail systemically (10(-14)-10(-12)M).
Gene_expression (production) of O-2 in PMN associated with dynorphin and opioid
1) Confidence 0.62 Published 1985 Journal Endocrinology Section Abstract Doc Link 2862014 Disease Relevance 0 Pain Relevance 0.34
Furthermore, salicylic acid in high concentrations did not impair the HMPS pathway, the production of O-2 or the production of H2O2 by granulocytes.
Gene_expression (production) of O-2 in granulocytes
2) Confidence 0.37 Published 1987 Journal J. Immunol. Section Abstract Doc Link 3031158 Disease Relevance 0.13 Pain Relevance 0.12
Furthermore, salicylic acid in high concentrations did not impair the HMPS pathway, the production of O-2 or the production of H2O2 by granulocytes.
Gene_expression (production) of O-2 in granulocytes
3) Confidence 0.29 Published 1987 Journal J. Immunol. Section Abstract Doc Link 3031158 Disease Relevance 0.13 Pain Relevance 0.13
These data provide evidence that salicylates are rapidly oxidized by the hydroxyl free radical produced by granulocytes and not O-2, H2O2, or HOCL.
Neg (not) Gene_expression (produced) of O-2 in granulocytes
4) Confidence 0.28 Published 1987 Journal J. Immunol. Section Abstract Doc Link 3031158 Disease Relevance 0.14 Pain Relevance 0.13
Enkephalinase inhibition increased O2- production from DADLE but not from DAGO treated PMNs.
Gene_expression (production) of O2
5) Confidence 0.25 Published 1995 Journal Neuropeptides Section Abstract Doc Link 8837964 Disease Relevance 0 Pain Relevance 1.19
Using human neutrophils as a source of O-2, and an assay for O-2 based upon the reduction of cytochrome C, we found that prostaglandin D2 (PGD2), leucine enkephalin (LE), and methionine enkephalin (ME) inhibited O-2 release.
Gene_expression (source) of O-2 in neutrophils associated with enkephalin
6) Confidence 0.11 Published 1986 Journal J. Surg. Res. Section Abstract Doc Link 3023754 Disease Relevance 0.29 Pain Relevance 0.62
Derivatives of superoxide (O-2), produced by phagocytic cells, are thought to play a role in the adult respiratory distress syndrome (ARDS) and other disease states.
Gene_expression (produced) of O-2 in respiratory associated with adult respiratory distress syndrome and disease
7) Confidence 0.11 Published 1986 Journal J. Surg. Res. Section Abstract Doc Link 3023754 Disease Relevance 0.29 Pain Relevance 0.47
Before N2O/O2 sedation, patients’ RSS were determined as 1 but after the administration of N2O/O2, at the T1-6 time points patients’ RSS were 2 and OAA/S scores of patients’ were 4 or 5.
Gene_expression (sedation) of O2 associated with sleep disorders
8) Confidence 0.11 Published 2007 Journal European journal of dentistry Section Body Doc Link PMC2609910 Disease Relevance 0.31 Pain Relevance 0
The aim of the current study was to assess any BIS changes during N2O/O2 sedation in pediatric dentistry.


Gene_expression (sedation) of O2 associated with sleep disorders
9) Confidence 0.11 Published 2007 Journal European journal of dentistry Section Body Doc Link PMC2609910 Disease Relevance 0.31 Pain Relevance 0.13
But Puri22 reported two cases with paradoxical changes in BIS during N2O administration.
Gene_expression (administration) of N2O
10) Confidence 0.11 Published 2007 Journal European journal of dentistry Section Body Doc Link PMC2609910 Disease Relevance 0.31 Pain Relevance 0.14
Before N2O/O2 sedation, patients’ RSS were determined as 1 but after the administration of N2O/O2, at the T1-6 time points patients’ RSS were 2 and OAA/S scores of patients’ were 4 or 5.
Gene_expression (sedation) of N2O associated with sleep disorders
11) Confidence 0.11 Published 2007 Journal European journal of dentistry Section Body Doc Link PMC2609910 Disease Relevance 0.31 Pain Relevance 0
The aim of the current study was to assess any BIS changes during N2O/O2 sedation in pediatric dentistry.


Gene_expression (sedation) of N2O associated with sleep disorders
12) Confidence 0.11 Published 2007 Journal European journal of dentistry Section Body Doc Link PMC2609910 Disease Relevance 0.31 Pain Relevance 0.13
Reactive Oxygen Species (ROS), such as O2-., are produced in all aerobic organisms during respiration and exist in the cell in equilibrium with endogenous antioxidants (e.g. glutathione, vitamins A, C and E).
Gene_expression (produced) of O2
13) Confidence 0.06 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1435878 Disease Relevance 0.14 Pain Relevance 0.04
Both NF161 and NF177 inhibited O2-. production and myeloperoxidase release from PMNs, challenged by FMLP, NF161 being statistically more active than NF177.
Gene_expression (production) of O2
14) Confidence 0.05 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1435878 Disease Relevance 0.70 Pain Relevance 0.20
Superoxide anion (O2-.) production
Gene_expression (production) of O2
15) Confidence 0.05 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1435878 Disease Relevance 0 Pain Relevance 0
This concentration was selected as suitable to produce optimal O2-. generation by human PMNs [26].
Gene_expression (produce) of O2
16) Confidence 0.05 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1435878 Disease Relevance 0.08 Pain Relevance 0.04
Neither of the tested compounds alone induced O2-. production by PMNs in the concentration range 10-6–10-4M (data not shown).
Gene_expression (production) of O2
17) Confidence 0.04 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1435878 Disease Relevance 0.09 Pain Relevance 0.04
Therefore the ability of these [1,8] naphthyridine derivatives to inhibit O2-. production demonstrates their role in modulating oxidative stress and suggests their potential use in various degenerative diseases.


Gene_expression (production) of O2 associated with stress and disease
18) Confidence 0.04 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1435878 Disease Relevance 0.64 Pain Relevance 0.04
Effect on O2-. production induced by FMLP on PMNs
Gene_expression (production) of O2
19) Confidence 0.04 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1435878 Disease Relevance 0.19 Pain Relevance 0.10
The compounds' effects on the production of reactive oxygen species (ROS) by human polymorphonuclear cells (PMNs) were studied in an in vitro cell model, evaluating inhibition of superoxide anion (O2-.) production induced by N-formylmethionyl-leucyl-phenylalanine (FMLP).
Gene_expression (production) of O2
20) Confidence 0.04 Published 2006 Journal J Inflamm (Lond) Section Abstract Doc Link PMC1435878 Disease Relevance 0.62 Pain Relevance 0.46

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