INT302956

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Context Info
Confidence 0.75
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.92
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Smpd3) Golgi apparatus (Smpd3) cell cycle (Smpd3)
response to stress (Smpd3)
Anatomy Link Frequency
leaflet 3
Smpd3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 12 98.92 Very High Very High Very High
Inflammation 16 79.72 Quite High
Inflammatory response 4 70.00 Quite High
metalloproteinase 4 65.52 Quite High
agonist 24 19.24 Low Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 252 99.80 Very High Very High Very High
Stress 76 98.08 Very High Very High Very High
Alzheimer's Dementia 8 97.76 Very High Very High Very High
Death 20 96.48 Very High Very High Very High
Targeted Disruption 8 87.80 High High
INFLAMMATION 20 79.72 Quite High
Toxicity 32 70.20 Quite High
Hepatotoxicity 8 52.32 Quite High
Osteogenesis Imperfecta 16 43.76 Quite Low
Leukemia 4 32.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All these data, suggest that nSMase2 is not required for apoptosis induced by TNF?
Neg (not) Localization (required) of nSMase2 associated with apoptosis
1) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843740 Disease Relevance 0.86 Pain Relevance 0
In contrast, nSMase2 is located on the inner leaflet, where it generates ceramide, hydrolyzed by ceramidases into sphingosine, which may be phosphorylated in turn by sphingosine kinase-1 [2], [4].
Localization (located) of nSMase2 in leaflet
2) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843740 Disease Relevance 0.63 Pain Relevance 0.07
The Mg2+-dependent nSMase2, encoded by SMPD3, is localized in the Golgi and the inner leaflet of the plasma membrane and is implicated in signaling triggered by cytokines, oxidative stress, amyloid ?
Localization (implicated) of nSMase2 in leaflet associated with stress, alzheimer's dementia and cytokine
3) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843740 Disease Relevance 0.73 Pain Relevance 0.09
The Mg2+-dependent nSMase2, encoded by SMPD3, is localized in the Golgi and the inner leaflet of the plasma membrane and is implicated in signaling triggered by cytokines, oxidative stress, amyloid ?
Localization (localized) of nSMase2 in leaflet associated with stress, alzheimer's dementia and cytokine
4) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843740 Disease Relevance 0.71 Pain Relevance 0.09

General Comments

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