INT302969

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.27
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Smpd3) Golgi apparatus (Smpd3) cell cycle (Smpd3)
response to stress (Smpd3)
Smpd3 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 12 68.56 Quite High
Inflammation 8 59.68 Quite High
cytokine 6 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 126 97.84 Very High Very High Very High
Toxicity 16 91.28 High High
Osteogenesis Imperfecta 8 80.88 Quite High
Stress 38 75.00 Quite High
Death 10 74.48 Quite High
INFLAMMATION 10 59.68 Quite High
Necrosis 6 25.56 Quite Low
Alzheimer's Dementia 4 5.00 Very Low Very Low Very Low
Hepatotoxicity 4 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the mitogenic response elicited by low concentrations of TNFalpha and oxidized LDLs (but not fetal calf serum) requires nSMase2 activation.


Positive_regulation (requires) of Positive_regulation (activation) of nSMase2
1) Confidence 0.50 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2843740 Disease Relevance 0.75 Pain Relevance 0.03
In these cells, the early phase (30–120 min) of SM hydrolysis and ceramide formation appears to be mainly attributable to nSMase2 activation.


Positive_regulation (attributable) of Positive_regulation (activation) of nSMase2
2) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843740 Disease Relevance 0.52 Pain Relevance 0.03

General Comments

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