INT302970

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Context Info
Confidence 0.58
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.97
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
fibroblasts 2
Smpd2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 12 14.20 Low Low
anesthesia 2 7.16 Low Low
Inflammation 8 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 126 96.44 Very High Very High Very High
Toxicity 16 75.72 Quite High
Stress 38 73.24 Quite High
Death 10 59.96 Quite High
Injury 2 38.00 Quite Low
INFLAMMATION 10 5.00 Very Low Very Low Very Low
Osteogenesis Imperfecta 8 5.00 Very Low Very Low Very Low
Necrosis 6 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 4 5.00 Very Low Very Low Very Low
Hepatotoxicity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Three clones expressing nSMase activity at least 3 times higher than wt fibroblasts were selected: in the paper the experiments were performed with ‘fro-V5smpd3 clone 3’.
Gene_expression (expressing) of nSMase in fibroblasts
1) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843740 Disease Relevance 0.15 Pain Relevance 0
In fro/fro fibroblasts expressing a V5-tagged nSMase2 (fro-V5 clone 3 fibroblasts) (Figure 4A), the basal level of nSMase activity was dramatically increased (around 3 times the level of wt) (Figure 4C).
Gene_expression (expressing) of nSMase in fibroblasts
2) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843740 Disease Relevance 0.82 Pain Relevance 0

General Comments

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