INT302980

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Context Info
Confidence 0.29
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.78
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Smpd3) response to stress (Smpd3) cytoplasm (Mmp2)
signal transduction (Smpd3) extracellular space (Mmp2) peptidase activity (Mmp2)
Mmp2 (Mus musculus)
Smpd3 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 1 99.74 Very High Very High Very High
Inflammation 4 12.28 Low Low
agonist 6 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 19 98.60 Very High Very High Very High
Apoptosis 63 88.56 High High
Leukemia 1 66.32 Quite High
Osteogenic Sarcomas 2 65.00 Quite High
Death 5 41.76 Quite Low
INFLAMMATION 5 12.28 Low Low
Toxicity 8 5.00 Very Low Very Low Very Low
Osteogenesis Imperfecta 4 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous reports had shown that the mitogenic response mediated by both stress-inducing agents, depends on furin and metalloproteinases MT1-MMP and MMP-2 which activate nSMase2, sphingomyelin hydrolysis, as well as the generation of sphingosine-1-phosphate by sphingosine kinase [8], [26].
MMP-2 Positive_regulation (activate) of nSMase2 associated with stress and metalloproteinase
1) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843740 Disease Relevance 0.78 Pain Relevance 0.05

General Comments

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