INT302982

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.64
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Smpd3) extracellular space (Smpd1) hydrolase activity, acting on glycosyl bonds (Smpd1)
Golgi apparatus (Smpd3) cell cycle (Smpd3) response to stress (Smpd3)
Anatomy Link Frequency
fibroblasts 2
Smpd1 (Mus musculus)
Smpd3 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 1 85.52 High High
Inflammatory response 1 38.16 Quite Low
agonist 6 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 19 98.48 Very High Very High Very High
Death 5 77.04 Quite High
Apoptosis 63 74.60 Quite High
Leukemia 1 52.36 Quite High
Osteogenic Sarcomas 2 51.04 Quite High
INFLAMMATION 5 38.16 Quite Low
Hepatotoxicity 2 20.48 Low Low
Toxicity 8 5.00 Very Low Very Low Very Low
Osteogenesis Imperfecta 4 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Note that the acid SMase, which is not deficient in fro/fro fibroblasts (data not shown), is unable to compensate for the defect in nSMase2-deficient cells.
SMase Neg (unable) Positive_regulation (compensate) of Gene_expression (defect) of nSMase2 in fibroblasts
1) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843740 Disease Relevance 0.64 Pain Relevance 0.04

General Comments

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