INT302990

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Context Info
Confidence 0.88
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.75
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MBP)
Anatomy Link Frequency
eosinophils 2
neuronal 1
cleavage 1
T cells 1
MBP (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 97 99.66 Very High Very High Very High
Demyelination 8 98.92 Very High Very High Very High
Multiple sclerosis 11 98.20 Very High Very High Very High
Inflammation 42 96.40 Very High Very High Very High
cytokine 11 79.56 Quite High
Nerve growth factor 8 73.72 Quite High
Pain 6 71.44 Quite High
Neuropathic pain 3 66.28 Quite High
Spinal cord 21 63.60 Quite High
agonist 2 48.44 Quite Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 20 99.92 Very High Very High Very High
Death 12 98.08 Very High Very High Very High
Asthma 44 96.48 Very High Very High Very High
Pulmonary Disease 10 96.48 Very High Very High Very High
INFLAMMATION 43 96.40 Very High Very High Very High
Spinal Cord Injury 63 93.56 High High
Bronchial Hyperreactivity 2 93.24 High High
Chronic Sinusitis 2 87.20 High High
Apoptosis 16 84.68 Quite High
Tendinopathy 2 70.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, our data support the hypothesis that eosinophil degranulation and release of MBP may occur within the airway wall and may contribute to the pathophysiology observed in asthma.
Protein_catabolism (degranulation) of MBP in eosinophil associated with asthma
1) Confidence 0.88 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0.26 Pain Relevance 0
In conclusion, in nonsensitized small human airway, eosinophils adhere, migrate within the airway wall, and undergo spontaneous degranulation of MBP.
Protein_catabolism (degranulation) of MBP in eosinophils
2) Confidence 0.66 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0.57 Pain Relevance 0.05
This leads to the further upregulation of the activity of multiple MMPs and the massive cleavage of MBP in the brain resulting in demyelination and MS [137].
Protein_catabolism (cleavage) of MBP in cleavage associated with multiple sclerosis, demyelination and metalloproteinase
3) Confidence 0.32 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 0.86 Pain Relevance 0.56
Proteolysis of the Golli-MBP isoforms by MMP-25 followed by the stimulation of the specific autoimmune T cells causes increased inflammation.
Protein_catabolism (Proteolysis) of MBP in T cells associated with inflammation
4) Confidence 0.32 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 0.88 Pain Relevance 0.52
TPA, a serine protease and a well-recognized thrombolytic agent, is considered to be involved in demyelinating diseases by degrading myelin basic protein (MBP) and contributing to excitotoxic neuronal death by activating microglia.
Protein_catabolism (degrading) of basic protein in neuronal associated with demyelinating disease and death
5) Confidence 0.01 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3019362 Disease Relevance 1.19 Pain Relevance 0.29

General Comments

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