INT3030

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.68
First Reported 1977
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 37
Total Number 38
Disease Relevance 5.58
Pain Relevance 19.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra2a) plasma membrane (Adra2a) cytoplasm (Adra2a)
signal transducer activity (Adra2a)
Anatomy Link Frequency
spinal cord 4
atrium 2
retina 1
brain 1
hippocampus 1
Adra2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 117 100.00 Very High Very High Very High
Clonidine 83 100.00 Very High Very High Very High
antagonist 51 100.00 Very High Very High Very High
Hyperalgesia 19 100.00 Very High Very High Very High
analgesia 11 100.00 Very High Very High Very High
opiate 9 100.00 Very High Very High Very High
antinociception 8 100.00 Very High Very High Very High
depression 5 100.00 Very High Very High Very High
intrathecal 5 99.98 Very High Very High Very High
Potency 16 99.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 19 100.00 Very High Very High Very High
Depression 5 100.00 Very High Very High Very High
Sleep Disorders 1 99.20 Very High Very High Very High
Neuropathic Pain 3 98.08 Very High Very High Very High
Increased Venous Pressure Under Development 4 97.88 Very High Very High Very High
Nervous System Injury 4 97.04 Very High Very High Very High
Stress 12 96.32 Very High Very High Very High
INFLAMMATION 1 96.28 Very High Very High Very High
Hypertension 12 95.68 Very High Very High Very High
Inflammatory Pain 1 90.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previously, we have shown that dexmedetomidine and clonidine act upon spinal alpha 2 adrenoceptor, which appeared distinguishable from that acted upon by ST-91.
Gene_expression (distinguishable) of alpha 2 adrenoceptor in spinal associated with clonidine
1) Confidence 0.68 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8093729 Disease Relevance 0 Pain Relevance 0.61
[Effects of desipramine and clomipramine on alpha 2-adrenergic receptor function in nucleus accumbens: studies with intracerebral dialysis in freely moving rats].
Gene_expression (function) of alpha 2-adrenergic in nucleus accumbens associated with nucleus accumbens and desipramine
2) Confidence 0.68 Published 1995 Journal Seishin Shinkeigaku Zasshi Section Title Doc Link 8532817 Disease Relevance 0 Pain Relevance 0.85
BACKGROUND: Intrathecally administered alpha2-adrenoceptor agonists produce effective antinociception, but sedation is an important adverse effect.
Gene_expression (produce) of alpha2-adrenoceptor associated with antinociception, agonist and sleep disorders
3) Confidence 0.67 Published 2000 Journal Anesthesiology Section Abstract Doc Link 10910498 Disease Relevance 0.17 Pain Relevance 0.42
The aim of this study was to investigate the expression of the alpha2-adrenergic receptors in the adrenal medulla, and to examine the mechanism by which clonidine and related drugs inhibit acetylcholine (ACh)-induced whole-cell currents in adrenal chromaffin cells.
Spec (investigate) Gene_expression (expression) of alpha2-adrenergic in chromaffin cells associated with medulla and clonidine
4) Confidence 0.66 Published 2001 Journal Auton Neurosci Section Abstract Doc Link 11474556 Disease Relevance 0 Pain Relevance 0.19
The spinal cord was removed, and spinal cord acetylcholine content, cholinergic neuron number and distribution, and alpha2-adrenergic receptor expression were determined.
Gene_expression (expression) of alpha2-adrenergic in spinal cord
5) Confidence 0.66 Published 2001 Journal Anesthesiology Section Body Doc Link 11465600 Disease Relevance 0.08 Pain Relevance 0
These results suggest that serotonergic spinal antinociceptive mechanisms are distinct from the mechanisms by which opioid receptor and alpha-2 adrenoceptor agonists produce antinociception in the spinal cord.
Gene_expression (produce) of alpha-2 adrenoceptor in spinal cord associated with antinociception, agonist, opioid receptor, antinociceptive and spinal cord
6) Confidence 0.65 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2455040 Disease Relevance 0.19 Pain Relevance 1.09
Using aerobic lactate production as an indicator of thermogenesis, we measured metabolic heat production in HT29 cells that expressed the gene encoding human vascular alpha 2-adrenergic receptors.
Gene_expression (expressed) of alpha 2-adrenergic
7) Confidence 0.65 Published 1996 Journal Hypertension Section Abstract Doc Link 8621203 Disease Relevance 0.44 Pain Relevance 0.21
It is suggested that DMI-facilitated FRA can be used as a test for alpha-2 adrenoceptor agonists which may act at presynaptic alpha-2 adrenoceptors in the spinal cord.
Gene_expression (agonists) of alpha-2 adrenoceptor in spinal cord associated with desipramine, agonist and spinal cord
8) Confidence 0.65 Published 1991 Journal J. Neural Transm. Gen. Sect. Section Abstract Doc Link 1675858 Disease Relevance 0 Pain Relevance 0.82
Although alpha 2 adrenoceptor agonists and antagonists produced changes in the baseline values of noradrenaline and DOPAC, they had little or no effect on stress-induced changes.
Gene_expression (produced) of alpha 2 adrenoceptor associated with stress, antagonist, noradrenaline and agonist
9) Confidence 0.65 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 7524966 Disease Relevance 0.58 Pain Relevance 0.49
One factor that is known to modulate both of these processes is the presynaptic alpha-2 adrenergic receptor.
Gene_expression (presynaptic) of alpha-2 adrenergic receptor
10) Confidence 0.63 Published 1993 Journal Brain Res. Section Abstract Doc Link 8098649 Disease Relevance 0.22 Pain Relevance 0.37
Opposite rank order of potency for alpha-2 adrenoceptor agonists on water and solute excretion in the rat: two sites and/or receptors?
Gene_expression (agonists) of alpha-2 adrenoceptor associated with agonist and potency
11) Confidence 0.63 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 1351096 Disease Relevance 0 Pain Relevance 0.65
Prazosin, an antagonist for alpha-1 adrenoceptors, enforced the alpha-2 adrenoceptor agonist-induced depression in both species. 6-Hydroxydopamine treatment, which reduced the norepinephrine concentrations in the rat cerebral cortex by 76%, increased the duration of the loss of righting reflex induced by xylazine indicating that central postsynaptic alpha-2 adrenoceptors might also be involved in this behavioral alteration.
Gene_expression (depression) of alpha-2 adrenoceptor in cerebral cortex associated with depression, antagonist, agonist and cerebral cortex
12) Confidence 0.61 Published 1989 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2572006 Disease Relevance 0.26 Pain Relevance 0.72
Calf retina membranes were selected as the alpha-2 adrenergic receptor source, and the alpha-2 antagonist [3H]RX821002 and the alpha-2 agonist [3H]clonidine were evaluated as radioligands.
Gene_expression (source) of alpha-2 adrenergic receptor in retina associated with antagonist, agonist and clonidine
13) Confidence 0.60 Published 1997 Journal J Pharm Sci Section Abstract Doc Link 9232523 Disease Relevance 0 Pain Relevance 0.39
Thus, idazoxan and Wy 27127 were equipotent alpha 2-adrenoceptor antagonists in vitro, however, the alpha 2:alpha 1 selectivity of Wy 27127 was considerably greater than that of idazoxan by virtue of weaker alpha 1-adrenoceptor antagonism.
Gene_expression (antagonists) of alpha 2-adrenoceptor associated with antagonist
14) Confidence 0.60 Published 1986 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2881217 Disease Relevance 0 Pain Relevance 0.39
The alpha 2-adrenoceptor agonists, UK 14,304, xylazine, B-HT 933, B-HT 920, clonidine and M-7, produced concentration-dependent prejunctional alpha 2-adrenoceptor-mediated inhibition of neurogenic responses in the guinea pig atrium and rat vas deferens and produced postjunctional alpha 2-adrenoceptor-mediated contraction of the canine saphenous vein.
Gene_expression (produced) of alpha 2-adrenoceptor-mediated in atrium associated with agonist and clonidine
15) Confidence 0.60 Published 1991 Journal Pharmacology Section Abstract Doc Link 1683709 Disease Relevance 0 Pain Relevance 0.39
The alpha 2-adrenoceptor agonists, UK 14,304, xylazine, B-HT 933, B-HT 920, clonidine and M-7, produced concentration-dependent prejunctional alpha 2-adrenoceptor-mediated inhibition of neurogenic responses in the guinea pig atrium and rat vas deferens and produced postjunctional alpha 2-adrenoceptor-mediated contraction of the canine saphenous vein.
Gene_expression (produced) of alpha 2-adrenoceptor-mediated in atrium associated with agonist and clonidine
16) Confidence 0.60 Published 1991 Journal Pharmacology Section Abstract Doc Link 1683709 Disease Relevance 0 Pain Relevance 0.37
We have previously shown that norepinephrine can produce hyperalgesia via an alpha 2-adrenergic receptor mechanism.
Gene_expression (produce) of alpha 2-adrenergic associated with hyperalgesia
17) Confidence 0.59 Published 1995 Journal Neuroscience Section Abstract Doc Link 7477883 Disease Relevance 0.36 Pain Relevance 0.83
The alpha 2-adrenergic receptor agonist clonidine has, however, also been shown to produce peripheral analgesia.
Gene_expression (produce) of alpha 2-adrenergic associated with agonist, analgesia and clonidine
18) Confidence 0.59 Published 1995 Journal Neuroscience Section Abstract Doc Link 7477883 Disease Relevance 0.38 Pain Relevance 0.93
Intrathecal pretreatment with antisense ODN to alpha2A-adrenergic receptors reduced alpha2A-adrenergic receptor protein expression compared with sense ODN control and also reduced clonidine-induced inhibition of [3H]NE release.
Gene_expression (expression) of alpha2A-adrenergic
19) Confidence 0.57 Published 2000 Journal Anesthesiology Section Body Doc Link 10861160 Disease Relevance 0 Pain Relevance 0
Recognizing that vascular alpha 2-adrenergic receptors mediate cold-induced vasoconstriction and that temperature maintenance is a primary thrust of cellular metabolism, we postulated that vascular alpha 2-adrenergic receptors contribute significantly to metabolic heat generation in homeotherms such as humans.
Gene_expression (contribute) of alpha 2-adrenergic associated with increased venous pressure under development
20) Confidence 0.56 Published 1996 Journal Hypertension Section Abstract Doc Link 8621203 Disease Relevance 0.36 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox