INT303023

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Context Info
Confidence 0.43
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.06
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
arterioles 1
bone marrow 1
Pah (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 3 75.36 Quite High
Inflammation 15 50.16 Quite High
cytokine 9 49.12 Quite Low
antagonist 36 5.00 Very Low Very Low Very Low
Serotonin 15 5.00 Very Low Very Low Very Low
fluoxetine 9 5.00 Very Low Very Low Very Low
aspirin 6 5.00 Very Low Very Low Very Low
cva 6 5.00 Very Low Very Low Very Low
sSRI 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 450 100.00 Very High Very High Very High
Hypoxia 21 98.16 Very High Very High Very High
Adhesions 6 93.56 High High
Hypertrophy 108 86.00 High High
Targeted Disruption 3 69.64 Quite High
Apoptosis 12 61.52 Quite High
INFLAMMATION 24 50.16 Quite High
Stress 3 39.72 Quite Low
Disease 15 9.96 Low Low
Increased Venous Pressure Under Development 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In another study the effect of bone marrow-derived cells on PAH induced by either MCT or exposure to chronic hypoxia in mice was investigated.
Protein_catabolism (on) of PAH in bone marrow associated with pulmonary hypertension and hypoxia
1) Confidence 0.43 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 0.57 Pain Relevance 0
I.v. administration of the active MCT metabolite (monocrotaline pyrrole, MCTp) to mice induced PAH within 15 days, due to remodeling of small pulmonary arterioles.
Protein_catabolism (days) of PAH in arterioles associated with pulmonary hypertension
2) Confidence 0.43 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 0.68 Pain Relevance 0
Intratracheal transfer of the human prostacyclin synthase (PGIS) gene to rats with MCT-induced PAH augmented pulmonary prostacyclin synthesis, ameliorated MCT-induced PAH, and improved survival in MCT rats [56].
Protein_catabolism (ameliorated) of PAH associated with pulmonary hypertension
3) Confidence 0.43 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 0.81 Pain Relevance 0.06

General Comments

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