INT303051

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Context Info
Confidence 0.56
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 18
Disease Relevance 2.46
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Mafk) DNA binding (Mafk)
Anatomy Link Frequency
neuronal 6
Mafk (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 306 98.64 Very High Very High Very High
anesthesia 18 93.04 High High
Neurotransmitter 90 91.68 High High
cytokine 18 15.28 Low Low
Disease Link Frequency Relevance Heat
Fibrosarcoma 36 99.58 Very High Very High Very High
Targeted Disruption 36 95.92 Very High Very High Very High
Increased Venous Pressure Under Development 72 80.72 Quite High
Neuroblastoma 54 80.64 Quite High
Pheochromocytoma 18 80.52 Quite High
Apoptosis 108 71.56 Quite High
Cancer 36 70.72 Quite High
Metastasis 18 63.28 Quite High
Fasciculation 18 45.76 Quite Low
Death 18 13.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we demonstrate that Akt downregulates the expression of several genes of neuronal functions, including MafK, SytI, and Syn-1, and some other genes such as Canx and Cadm1 (Table 2).
Gene_expression (expression) of MafK in neuronal
1) Confidence 0.56 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.27 Pain Relevance 0
Taken together, these results indicate that Akt downregulates the expression of MafK, SytI, and Syn-1.
Gene_expression (expression) of MafK
2) Confidence 0.56 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.11 Pain Relevance 0.18
Inhibition of MafK expression has been reported to suppress neurite generation in PC12 cells treated with NGF and in primary immature neuronal cells [22], and mice deficient in MafK and MafG suffer from neurological dysfunction [37].
Gene_expression (expression) of MafK in neuronal associated with anesthesia and nerve growth factor
3) Confidence 0.56 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.13 Pain Relevance 0.21
Effect of an Akt-specific inhibitor on expression of MafK, SytI, and Syn-1 genes in PC12 (WT-Akt) cells
Gene_expression (expression) of MafK
4) Confidence 0.56 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.05 Pain Relevance 0
In this regard, it remains to be determined whether MafK and Syn-1 gene expressions are altered by expressing the active or dominant-negative (or silencing) form of C/EBP and Ngn2 in PC (WT-Akt) and PC (DN-Akt) cells, respectively.
Gene_expression (expressions) of MafK
5) Confidence 0.49 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.05 Pain Relevance 0.03
In agreement with the transcript levels, MafK, SytI, and Syn-1 protein levels were also higher in PC (DN-Akt) cells than in PC (WT-Akt) cells.


Gene_expression (levels) of MafK
6) Confidence 0.49 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.06 Pain Relevance 0
inhibitor on expression of MafK, SytI, and Syn-1 genes in PC12 (DN-Akt) cells
Gene_expression (expression) of MafK
7) Confidence 0.44 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0 Pain Relevance 0
Therefore, it is alleged that Akt downregulates the expression of MafK, SytI, and Syn-1 genes, all of which are positively related to neuronal function.


Gene_expression (expression) of MafK in neuronal
8) Confidence 0.44 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.06 Pain Relevance 0.12
However, the increased expression of MafK and Syn-1 genes in PC12 (WT-Akt) cells upon pharmacological inhibition of Gsk3?
Gene_expression (expression) of MafK
9) Confidence 0.44 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.29 Pain Relevance 0.04
These results indicate that dominant-negative or pharmacological inhibition of Akt increases the expression of MafK, SytI, and Syn-1 genes.
Gene_expression (expression) of MafK
10) Confidence 0.44 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2844376 Disease Relevance 0.24 Pain Relevance 0.04
Akt regulates the expression of MafK, synaptotagmin I, and syntenin-1, which play roles in neuronal function

Background

Gene_expression (expression) of MafK in neuronal
11) Confidence 0.44 Published 2010 Journal J Biomed Sci Section Title Doc Link PMC2844376 Disease Relevance 0.12 Pain Relevance 0.03
Using PC12 cells expressing wild-type or dominant-negative Akt and also using a pharmacological inhibitor of Akt, we demonstrate that Akt can negatively affect the expression of MafK, SytI, and Syn-1 genes.
Gene_expression (expression) of MafK
12) Confidence 0.44 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0 Pain Relevance 0.05
These data, together, indicate that Akt downregulates the levels of MafK, SytI, and Syn-1 transcripts.
Gene_expression (levels) of MafK
13) Confidence 0.44 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0 Pain Relevance 0.07
We then measured the transcript levels of MafK, SytI, and Syn-1 using semi-quantitative PCR.
Gene_expression (levels) of MafK
14) Confidence 0.44 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0 Pain Relevance 0.09
Approximately seventy genes including v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (MafK), synaptotagmin I (SytI), and syntenin-1 (Syn-1) were recognized as genes expressed at a higher level in cells that express have PC12 (DN-Akt) cells.
Gene_expression (express) of MafK associated with fibrosarcoma
15) Confidence 0.44 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.44 Pain Relevance 0.04
In summary, Akt regulates the expression of MafK, SytI, and Syn-1, which are all neuronal function-related genes.


Gene_expression (expression) of MafK in neuronal
16) Confidence 0.44 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0 Pain Relevance 0.05
Taken together, these results indicate that Akt negatively regulates the expression of MafK, SytI, and Syn-1 genes that all participate in regulating neuronal integrity in some way or another.



Gene_expression (expression) of MafK in neuronal
17) Confidence 0.44 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2844376 Disease Relevance 0.22 Pain Relevance 0.03
Approximately seventy genes including v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (MafK), synaptotagmin I (SytI), and syntenin-1 (Syn-1) were recognized as genes expressed at a higher level in cells that express have PC12 (DN-Akt) cells.
Gene_expression (expressed) of MafK associated with fibrosarcoma
18) Confidence 0.44 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.44 Pain Relevance 0.04

General Comments

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