INT303058

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.43
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Akt1, Syt1) plasma membrane (Akt1, Syt1) nucleoplasm (Akt1)
transport (Akt1) aging (Akt1) enzyme binding (Akt1)
Anatomy Link Frequency
neuronal 2
Akt1 (Rattus norvegicus)
Syt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 51 85.04 High High
anesthesia 3 77.28 Quite High
Neurotransmitter 15 67.20 Quite High
cytokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 9 75.28 Quite High
Cancer 6 71.20 Quite High
Increased Venous Pressure Under Development 12 54.76 Quite High
Metastasis 3 54.48 Quite High
Fasciculation 3 36.96 Quite Low
Targeted Disruption 6 26.28 Quite Low
Death 3 14.60 Low Low
Injury 3 13.60 Low Low
Apoptosis 18 5.00 Very Low Very Low Very Low
Infection 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of an Akt-specific inhibitor on expression of MafK, SytI, and Syn-1 genes in PC12 (WT-Akt) cells
Akt Negative_regulation (inhibitor) of Gene_expression (expression) of SytI
1) Confidence 0.21 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.05 Pain Relevance 0
In the present study, we demonstrate that Akt downregulates the expression of several genes of neuronal functions, including MafK, SytI, and Syn-1, and some other genes such as Canx and Cadm1 (Table 2).
Akt Negative_regulation (downregulates) of Gene_expression (expression) of SytI in neuronal
2) Confidence 0.21 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.27 Pain Relevance 0
Taken together, these results indicate that Akt downregulates the expression of MafK, SytI, and Syn-1.
Akt Negative_regulation (downregulates) of Gene_expression (expression) of SytI
3) Confidence 0.21 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.11 Pain Relevance 0.18

General Comments

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