INT303063

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.45
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Akt1) transport (Akt1) aging (Akt1)
Golgi apparatus (Syn1) enzyme binding (Akt1) carbohydrate metabolic process (Akt1)
Anatomy Link Frequency
neuronal 4
Akt1 (Rattus norvegicus)
Syn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 51 85.92 High High
Neurotransmitter 15 84.36 Quite High
anesthesia 3 78.16 Quite High
cytokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 9 76.16 Quite High
Cancer 6 72.08 Quite High
Fibrosarcoma 6 65.16 Quite High
Metastasis 3 55.36 Quite High
Pheochromocytoma 3 46.52 Quite Low
Fasciculation 3 37.84 Quite Low
Apoptosis 18 37.56 Quite Low
Targeted Disruption 6 26.28 Quite Low
Death 3 14.60 Low Low
Increased Venous Pressure Under Development 12 13.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we demonstrate that Akt downregulates the expression of several genes of neuronal functions, including MafK, SytI, and Syn-1, and some other genes such as Canx and Cadm1 (Table 2).
Akt Negative_regulation (downregulates) of Gene_expression (expression) of Syn-1 in neuronal
1) Confidence 0.09 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.27 Pain Relevance 0
Taken together, these results indicate that Akt downregulates the expression of MafK, SytI, and Syn-1.
Akt Negative_regulation (downregulates) of Gene_expression (expression) of Syn-1
2) Confidence 0.09 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.11 Pain Relevance 0.19
Therefore, it is alleged that Akt downregulates the expression of MafK, SytI, and Syn-1 genes, all of which are positively related to neuronal function.


Akt Negative_regulation (downregulates) of Gene_expression (expression) of Syn-1 in neuronal
3) Confidence 0.06 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.07 Pain Relevance 0.12

General Comments

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