INT303085

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Context Info
Confidence 0.12
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 3
Disease Relevance 0.33
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Akt1, Mafk) nucleoplasm (Akt1) transport (Akt1)
aging (Akt1) DNA binding (Mafk) enzyme binding (Akt1)
Anatomy Link Frequency
neuronal 4
Akt1 (Rattus norvegicus)
Mafk (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 15 91.68 High High
Nerve growth factor 51 11.68 Low Low
cytokine 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 6 92.76 High High
Increased Venous Pressure Under Development 12 70.52 Quite High
Fibrosarcoma 6 65.56 Quite High
Neuroblastoma 9 6.12 Low Low
Apoptosis 18 5.00 Very Low Very Low Very Low
Infection 9 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
Metastasis 3 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these results indicate that Akt negatively regulates the expression of MafK, SytI, and Syn-1 genes that all participate in regulating neuronal integrity in some way or another.



Akt Regulation (regulates) of Gene_expression (expression) of MafK in neuronal
1) Confidence 0.12 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2844376 Disease Relevance 0.22 Pain Relevance 0.03
Using PC12 cells expressing wild-type or dominant-negative Akt and also using a pharmacological inhibitor of Akt, we demonstrate that Akt can negatively affect the expression of MafK, SytI, and Syn-1 genes.
Akt Regulation (affect) of Gene_expression (expression) of MafK
2) Confidence 0.12 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0 Pain Relevance 0.05
Akt regulates the expression of MafK, synaptotagmin I, and syntenin-1, which play roles in neuronal function

Background

Akt Regulation (regulates) of Gene_expression (expression) of MafK in neuronal
3) Confidence 0.12 Published 2010 Journal J Biomed Sci Section Title Doc Link PMC2844376 Disease Relevance 0.12 Pain Relevance 0.03

General Comments

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