INT30312

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Context Info
Confidence 0.37
First Reported 1982
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 30
Total Number 30
Disease Relevance 4.20
Pain Relevance 18.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pdyn) plasma membrane (Pdyn)
Anatomy Link Frequency
brain 3
spinal cord 1
caudate putamen 1
cleavage 1
olfactory tubercle 1
Pdyn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 184 100.00 Very High Very High Very High
Enkephalin 43 100.00 Very High Very High Very High
Opioid 39 100.00 Very High Very High Very High
Kappa opioid receptor 15 100.00 Very High Very High Very High
Morphine 1 100.00 Very High Very High Very High
opioid receptor 11 99.68 Very High Very High Very High
Neuropeptide 6 99.24 Very High Very High Very High
narcan 5 99.12 Very High Very High Very High
Dopamine 1 98.80 Very High Very High Very High
Nucleus accumbens 18 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Epilepsy 11 99.76 Very High Very High Very High
Eczema 8 99.24 Very High Very High Very High
Pressure And Volume Under Development 8 97.16 Very High Very High Very High
Pruritus 8 95.68 Very High Very High Very High
Alcohol Addiction 3 95.12 Very High Very High Very High
Closed Head Injuries 8 94.52 High High
Sclerosis 1 92.40 High High
Brain Injury 1 91.84 High High
Brain Disease 4 90.96 High High
Catatonia 1 85.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transcriptionally less active prodynorphin promoter alleles are associated with temporal lobe epilepsy: a case-control study and meta-analysis.
prodynorphin Binding (associated) of in temporal lobe associated with epilepsy and enkephalin
1) Confidence 0.37 Published 2008 Journal Dis. Markers Section Title Doc Link 18334734 Disease Relevance 0.80 Pain Relevance 0.10
No significant association of the PDYN promoter polymorphism with AD in general was found when patients with AD were compared with controls.
PDYN promoter Neg (No) Binding (association) of associated with eczema
2) Confidence 0.37 Published 2009 Journal Clin. Exp. Dermatol. Section Abstract Doc Link 19486061 Disease Relevance 1.43 Pain Relevance 0.41
Baseline levels and topographical distribution of preprodynorphin mRNA remained unchanged. kappa-opioid receptor binding was analyzed in membrane from nucleus accumbens + olfactory tubercle, caudate putamen, and midbrain of male and female offspring using [3h]U69593.
preprodynorphin Binding (binding) of in caudate putamen associated with nucleus accumbens, kappa opioid receptor and midbrain
3) Confidence 0.37 Published 1997 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 9027410 Disease Relevance 0 Pain Relevance 0.45
Characterization of the prodynorphin and proenkephalin neuropeptide systems in rat hippocampus.
prodynorphin Binding (Characterization) of in hippocampus associated with neuropeptide, enkephalin and hippocampus
4) Confidence 0.36 Published 1985 Journal J. Neurosci. Section Title Doc Link 3838345 Disease Relevance 0 Pain Relevance 0.87
These results suggest that the same enzyme may be responsible for the formation of dynorphin B-14 and dynorphin B.
dynorphin B Binding (formation) of associated with dynorphin
5) Confidence 0.34 Published 1986 Journal J. Neurochem. Section Abstract Doc Link 2872272 Disease Relevance 0 Pain Relevance 0.54
These results suggest that the same enzyme may be responsible for the formation of dynorphin B-14 and dynorphin B.
dynorphin B Binding (formation) of associated with dynorphin
6) Confidence 0.34 Published 1986 Journal J. Neurochem. Section Abstract Doc Link 2872272 Disease Relevance 0 Pain Relevance 0.54
Both temperature and pH had similar effects on the formation of dynorphin B-14 and dynorphin B.
dynorphin B Binding (formation) of associated with dynorphin
7) Confidence 0.33 Published 1986 Journal J. Neurochem. Section Abstract Doc Link 2872272 Disease Relevance 0 Pain Relevance 0.56
These findings suggest an interaction between peptides from the proenkephalin B precursor and nigro-striatal dopamine neurons as well as gabaergic striato-nigral efferents and/or interneurons.
proenkephalin B Binding (interaction) of in dopamine neurons associated with dopamine
8) Confidence 0.31 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6148248 Disease Relevance 0 Pain Relevance 0.80
Haplotype analyses further supported the association of PDYN.
PDYN Binding (association) of
9) Confidence 0.28 Published 2006 Journal Mol. Psychiatry Section Abstract Doc Link 16924269 Disease Relevance 0.26 Pain Relevance 0.70
Thus the formation of dynorphin B does not involve the action of a trypsin-like enzyme followed by removal of arginine-14 by a carboxypeptidase B-like enzyme.
dynorphin B Binding (formation) of associated with dynorphin
10) Confidence 0.26 Published 1985 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2862869 Disease Relevance 0 Pain Relevance 0.71
Correlation analyses revealed that significant associations between dynorphin A or dynorphin B and Leu-enkephalin-Arg(6) were found more often during estrus than during the diestrus and proestrus conditions.
dynorphin Binding (associations) of associated with dynorphin and enkephalin
11) Confidence 0.25 Published 2006 Journal Neuropeptides Section Abstract Doc Link 16540166 Disease Relevance 0 Pain Relevance 1.33
Correlation analyses revealed that significant associations between dynorphin A or dynorphin B and Leu-enkephalin-Arg(6) were found more often during estrus than during the diestrus and proestrus conditions.
dynorphin Binding (associations) of associated with dynorphin and enkephalin
12) Confidence 0.25 Published 2006 Journal Neuropeptides Section Abstract Doc Link 16540166 Disease Relevance 0 Pain Relevance 1.33
The present report describes and validates a radioimmunoassay for dynorphin B using an antiserum, "13S", that does not crossreact with other known opioid peptides.
dynorphin B Neg (not) Binding (crossreact) of associated with dynorphin and opioid
13) Confidence 0.24 Published 1982 Journal Neuropeptides Section Abstract Doc Link 7162565 Disease Relevance 0 Pain Relevance 0.76
By means of proline-specific endopeptidase hydrolysis, we also found a big dynorphin precursor (Mr approximately equal to 26 kDa) in both brain and spinal cord.
dynorphin Binding (found) of in brain associated with dynorphin and spinal cord
14) Confidence 0.18 Published 1987 Journal J. Neurosci. Section Abstract Doc Link 2886564 Disease Relevance 0 Pain Relevance 0.85
Associated with the Golgi membranes a putative opioid peptide processing activity was demonstrated, which acts on Dynorphin 1-13, alpha- and beta-Neoendorphin.
beta-Neoendorphin Binding (acts) of associated with dynorphin and opioid
15) Confidence 0.17 Published 1986 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 3527160 Disease Relevance 0 Pain Relevance 0.32
We have developed a radioimmunoassay for synthetic dynorphin B, a novel opioid tridecapeptide, which shares a common precursor molecule with dynorphin1-17 (= dynorphin A) and the neo-endorphins.
dynorphin B Binding (radioimmunoassay) of associated with dynorphin and opioid
16) Confidence 0.16 Published 1983 Journal Peptides Section Abstract Doc Link 6143300 Disease Relevance 0 Pain Relevance 0.37
The antiserum used was highly specific with only dynorphin-32 and dynorphin B-29, both of which contain the dynorphin B sequence, showing substantial cross-reactivity.
dynorphin B Binding (specific) of associated with dynorphin
17) Confidence 0.14 Published 1983 Journal Peptides Section Abstract Doc Link 6143300 Disease Relevance 0 Pain Relevance 0.41
Baseline levels and topographical distribution of preprodynorphin mRNA remained unchanged. kappa-opioid receptor binding was analyzed in membrane from nucleus accumbens + olfactory tubercle, caudate putamen, and midbrain of male and female offspring using [3h]U69593.
preprodynorphin Binding (binding) of in olfactory tubercle associated with nucleus accumbens, kappa opioid receptor and midbrain
18) Confidence 0.13 Published 1997 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 9027410 Disease Relevance 0 Pain Relevance 0.45
Baseline levels and topographical distribution of preprodynorphin mRNA remained unchanged. kappa-opioid receptor binding was analyzed in membrane from nucleus accumbens + olfactory tubercle, caudate putamen, and midbrain of male and female offspring using [3h]U69593.
preprodynorphin Binding (binding) of in midbrain associated with nucleus accumbens, kappa opioid receptor and midbrain
19) Confidence 0.13 Published 1997 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 9027410 Disease Relevance 0 Pain Relevance 0.45
Kappa 1 receptor mRNA distribution in the rat CNS: comparison to kappa receptor binding and prodynorphin mRNA.
prodynorphin mRNA Binding (binding) of associated with enkephalin
20) Confidence 0.11 Published 1994 Journal Mol. Cell. Neurosci. Section Title Doc Link 8032682 Disease Relevance 0.05 Pain Relevance 0.18

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