INT30314

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Context Info
Confidence 0.34
First Reported 1985
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.08
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptgir) signal transducer activity (Ptgir)
Anatomy Link Frequency
endothelial cells 1
Ptgir (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cva 3 100.00 Very High Very High Very High
Morphine 3 100.00 Very High Very High Very High
Restless leg syndrome 1 92.64 High High
agonist 6 86.84 High High
Analgesic 3 86.08 High High
antagonist 17 76.68 Quite High
Antinociceptive 1 75.00 Quite High
Pain 3 27.28 Quite Low
headache 2 26.80 Quite Low
Calcium channel 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 106 97.74 Very High Very High Very High
Increased Venous Pressure Under Development 20 96.60 Very High Very High Very High
Catalepsy 2 93.36 High High
Hypothermia 1 83.92 Quite High
Syndrome 6 71.72 Quite High
Toxicity 1 66.40 Quite High
Cv General 4 Under Development 9 58.56 Quite High
Disease 10 54.68 Quite High
Hepatotoxicity 1 32.32 Quite Low
Pain 2 27.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Defects in the prostaglandin system.
Negative_regulation ([Defects) of platelet-prostacyclin receptor associated with cva
1) Confidence 0.34 Published 1985 Journal Wien. Klin. Wochenschr. Section Title Doc Link 2986363 Disease Relevance 0.19 Pain Relevance 0.14
CMT blocks cataleptogenic effect of chloropromazine and morphine as well as the combination of these two substances with PGI2.
Negative_regulation (blocks) of PGI2 associated with morphine
2) Confidence 0.30 Published 1985 Journal Biomed. Biochim. Acta Section Abstract Doc Link 2862862 Disease Relevance 0.26 Pain Relevance 0.49
In patients with pulmonary hypertension, pulmonary endothelial cells have decreased expression of prostacyclin synthase89 and urinalysis demonstrates a decrease in stable prostacyclin metabolites.26
Negative_regulation (decrease) of prostacyclin in endothelial cells associated with pulmonary hypertension
3) Confidence 0.03 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2697585 Disease Relevance 0.63 Pain Relevance 0.12

General Comments

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