INT303159

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Trim3, Shank1) cytoplasm (Trim3, Shank1) cell differentiation (Shank1)
plasma membrane (Shank1) protein complex assembly (Shank1)
Trim3 (Rattus norvegicus)
Shank1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 8 5.00 Very Low Very Low Very Low
Glutamate receptor 4 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 2 5.00 Very Low Very Low Very Low
Intellectual Impairment 2 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Autism 2 5.00 Very Low Very Low Very Low
Angelman Syndrome 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data strongly support the idea that TRIM3 suppresses GKAP protein expression by stimulating UPS-mediated degradation of GKAP.
TRIM3 Negative_regulation (suppresses) of Gene_expression (expression) of GKAP protein
1) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0 Pain Relevance 0
At least in heterologous cells, therefore, the inhibition of Shank1A protein levels by TRIM3 appears to be unrelated to the E3 ligase activity of TRIM3.
TRIM3 Negative_regulation (inhibition) of Gene_expression (levels) of Shank1A protein
2) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox