INT30316

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Context Info
Confidence 0.43
First Reported 1985
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 1.95
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CHAT) mitochondrion (CHAT) nucleus (CHAT)
transferase activity, transferring acyl groups (CHAT) cytoplasm (CHAT)
Anatomy Link Frequency
body 2
neuronal 1
uterus 1
brains 1
CHAT (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 2 97.60 Very High Very High Very High
Enkephalin 66 89.72 High High
opiate 2 89.12 High High
withdrawal 4 87.32 High High
projection neuron 20 86.44 High High
Neurotransmitter 2 75.80 Quite High
Pain 3 72.40 Quite High
Central nervous system 1 61.28 Quite High
interneuron 8 5.00 Very Low Very Low Very Low
GABAergic 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Scotoma 20 99.36 Very High Very High Very High
Death 1 99.36 Very High Very High Very High
Tendinopathy 9 98.40 Very High Very High Very High
Hyperplasia 1 97.28 Very High Very High Very High
Alcohol Addiction 1 86.00 High High
Age-related Macular Degeneration 18 83.36 Quite High
Glaucoma 18 82.72 Quite High
Urological Neuroanatomy 1 81.92 Quite High
Cognitive Disorder 6 76.96 Quite High
Ganglion Cysts 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoreaction for ChAT and VAChT was detected in tenocytes in tendinosis specimens, particularly in aberrant cells.
Regulation (Immunoreaction) of ChAT associated with tendinopathy
1) Confidence 0.43 Published 2008 Journal Cell Tissue Res. Section Abstract Doc Link 17999088 Disease Relevance 0.81 Pain Relevance 0.14
Similarly, no changes in the activities of choline acetyltransferase, tyrosine hydroxylase or MAO-B were observed in brains of alcoholics as compared to the control population.
Neg (no) Regulation (changes) of choline acetyltransferase in brains
2) Confidence 0.32 Published 1985 Journal Alcohol Section Abstract Doc Link 2862881 Disease Relevance 0.27 Pain Relevance 0.38
This study was carried out using stereological methods to examine the volume and density (cells/mm3) of these interneurons, as visualized by choline acetyltransferase (ChAT) immunoreactivity, in the following territories of the CN and Put of nine normal human brains: 1) precommissural head; 2) postcommissural head; 3) body; 4) gyrus and 5) tail of the CN; 6) precommissural and 7) postcommissural Put.
Regulation (immunoreactivity) of choline acetyltransferase in body
3) Confidence 0.16 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2137841 Disease Relevance 0.08 Pain Relevance 0.08
This study was carried out using stereological methods to examine the volume and density (cells/mm3) of these interneurons, as visualized by choline acetyltransferase (ChAT) immunoreactivity, in the following territories of the CN and Put of nine normal human brains: 1) precommissural head; 2) postcommissural head; 3) body; 4) gyrus and 5) tail of the CN; 6) precommissural and 7) postcommissural Put.
Regulation (immunoreactivity) of ChAT in body
4) Confidence 0.16 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2137841 Disease Relevance 0.08 Pain Relevance 0.08
Choline acetyltransferase (ChAT), Met-ENK, and NT immunoreactivity was detected with light microscopy in axon terminals near tyrosine hydroxylase (TH) immunoreactive (IR) cells.
Regulation (immunoreactivity) of ChAT
5) Confidence 0.04 Published 2002 Journal Synapse Section Abstract Doc Link 11793421 Disease Relevance 0.13 Pain Relevance 0.16
It is not known what brings about the changes in PGR expression in the uterus at the time of parturition; however it is possible that these are mediated by changes in histone acetylase activity which is required for PGR transcription.
Regulation (changes) of histone acetylase in uterus
6) Confidence 0.00 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892059 Disease Relevance 0 Pain Relevance 0.07
In this paper, we studied if the concentrations in the occipital brain of the metabolites N-acetylaspartate (NAA) (a marker of neuronal integrity), Creatine (Cr) and Choline (Cho) are affected by progressive visual field defects.
Regulation (affected) of Choline in neuronal associated with scotoma
7) Confidence 0.00 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1794168 Disease Relevance 0.59 Pain Relevance 0.03

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