INT303175

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Context Info
Confidence 0.28
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dlgap1) intracellular (Trim3) cell-cell signaling (Dlgap1)
cytoplasm (Trim3)
Anatomy Link Frequency
neurons 2
Trim3 (Rattus norvegicus)
Dlgap1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 4 5.00 Very Low Very Low Very Low
Glutamate receptor 2 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 2 5.00 Very Low Very Low Very Low
Anxiety Disorder 1 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 1 5.00 Very Low Very Low Very Low
Intellectual Impairment 1 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Autism 1 5.00 Very Low Very Low Very Low
Angelman Syndrome 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(i) TRIM3 stimulates the ubiquitination and loss of GKAP in heterologous cells, dependent on the RING finger of TRIM3 and on proteasome function; (ii) overexpression of TRIM3 leads to the depletion of endogenous GKAP in neurons; (iii) RNAi knockdown of endogenous TRIM3 in neurons results in elevated levels of postsynaptic GKAP.
TRIM3 Positive_regulation (stimulates) of Negative_regulation (loss) of GKAP in neurons
1) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0 Pain Relevance 0

General Comments

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