INT303176

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Context Info
Confidence 0.44
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Trim3, Shank1) cytoplasm (Trim3, Shank1) cell differentiation (Shank1)
plasma membrane (Shank1) protein complex assembly (Shank1)
Trim3 (Rattus norvegicus)
Shank1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 4 71.12 Quite High
Glutamate receptor 2 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 2 5.00 Very Low Very Low Very Low
Anxiety Disorder 1 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 1 5.00 Very Low Very Low Very Low
Intellectual Impairment 1 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Autism 1 5.00 Very Low Very Low Very Low
Angelman Syndrome 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We therefore tested in heterologous cells whether overexpression of TRIM3 can stimulate the degradation of Shank1A or GKAP/SAPAP1, another abundant PSD scaffold that is implicated in Shank1 accumulation in the PSD [16], [17].
Gene_expression (overexpression) of TRIM3 Positive_regulation (stimulate) of Protein_catabolism (degradation) of Shank1A
1) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0 Pain Relevance 0.07

General Comments

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