INT303177

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.13
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dlgap1) intracellular (Trim3) cell-cell signaling (Dlgap1)
cytoplasm (Trim3)
Trim3 (Rattus norvegicus)
Dlgap1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 8 90.96 High High
tetrodotoxin 16 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 8 66.28 Quite High
Disease 4 59.12 Quite High
Intellectual Impairment 4 16.40 Low Low
Angelman Syndrome 4 13.60 Low Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 4 5.00 Very Low Very Low Very Low
Cognitive Disorder 4 5.00 Very Low Very Low Very Low
Autism 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Collectively, these data suggest that TRIM3 stimulates GKAP degradation by acting as a specific ubiquitin ligase for GKAP.


TRIM3 Positive_regulation (stimulates) of Protein_catabolism (degradation) of GKAP
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0 Pain Relevance 0
Overall, our data indicate that GKAP is more likely than Shank1A to be a conventional substrate of TRIM3-mediated UPS degradation.
TRIM3 Positive_regulation (mediated) of Protein_catabolism (degradation) of GKAP
2) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0 Pain Relevance 0
These data strongly support the idea that TRIM3 suppresses GKAP protein expression by stimulating UPS-mediated degradation of GKAP.
TRIM3 Positive_regulation (stimulating) of Protein_catabolism (degradation) of GKAP
3) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0 Pain Relevance 0
TRIM3 induces ubiquitination and proteasome-dependent degradation of GKAP in heterologous cells.
TRIM3 Positive_regulation (induces) of Protein_catabolism (degradation) of GKAP
4) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0.13 Pain Relevance 0.05

General Comments

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