INT303179

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Context Info
Confidence 0.22
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.31
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dlgap1, Shank1) cell differentiation (Shank1) intracellular (Shank1)
protein complex assembly (Shank1) cytoplasm (Shank1) cell-cell signaling (Dlgap1)
Anatomy Link Frequency
Shank 4
synapses 2
Dlgap1 (Rattus norvegicus)
Shank1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 12 100.00 Very High Very High Very High
tetrodotoxin 24 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 12 80.16 Quite High
Disease 6 73.00 Quite High
Anxiety Disorder 6 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 6 5.00 Very Low Very Low Very Low
Intellectual Impairment 6 5.00 Very Low Very Low Very Low
Cognitive Disorder 6 5.00 Very Low Very Low Very Low
Autism 6 5.00 Very Low Very Low Very Low
Angelman Syndrome 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is known that Shank proteins bind directly to GKAP through an interaction between the Shank PDZ domain and the C-terminus of GKAP.
GKAP Binding (interaction) of Shank in Shank
1) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0 Pain Relevance 0
By binding to both Shank and PSD-95, GKAP links Shank to the PSD-95 protein complex, including NMDA-type glutamate receptors [16], [17] GKAP and Shank protein levels in synapses are regulated by activity and they are among the most prominently ubiquitinated proteins in the PSD [3].
GKAP Binding (binding) of Shank in synapses associated with glutamate receptor
2) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0.15 Pain Relevance 0.05
By binding to both Shank and PSD-95, GKAP links Shank to the PSD-95 protein complex, including NMDA-type glutamate receptors [16], [17] GKAP and Shank protein levels in synapses are regulated by activity and they are among the most prominently ubiquitinated proteins in the PSD [3].
GKAP Binding (binding) of Shank in synapses associated with glutamate receptor
3) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0.15 Pain Relevance 0.05
It is known that Shank proteins bind directly to GKAP through an interaction between the Shank PDZ domain and the C-terminus of GKAP.
GKAP Binding (interaction) of Shank in Shank
4) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0 Pain Relevance 0
It is known that Shank proteins bind directly to GKAP through an interaction between the Shank PDZ domain and the C-terminus of GKAP.
GKAP Binding (interaction) of Shank in Shank
5) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0 Pain Relevance 0
It is known that Shank proteins bind directly to GKAP through an interaction between the Shank PDZ domain and the C-terminus of GKAP.
GKAP Binding (bind) of Shank in Shank
6) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0 Pain Relevance 0

General Comments

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