INT303193

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Context Info
Confidence 0.62
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.19
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Shank1) plasma membrane (Shank1) intracellular (Shank1)
protein complex assembly (Shank1) cytoplasm (Shank1)
Anatomy Link Frequency
Shank 1
synapses 1
Shank1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 6 9.00 Low Low
tetrodotoxin 12 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Angelman Syndrome 3 64.84 Quite High
Syndrome 6 63.84 Quite High
Intellectual Impairment 3 63.48 Quite High
Anxiety Disorder 3 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 3 5.00 Very Low Very Low Very Low
Cognitive Disorder 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Autism 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, proteasomal inhibition by MG-132 did not fully prevent the decrease in Shank1A induced by cotransfection of TRIM3 (data not shown).
Localization (decrease) of Shank1A
1) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0 Pain Relevance 0
In addition to being itself a target of UPS degradation [3], Shank1A is localized to synapses, and its accumulation requires other scaffold proteins in the PSD, including GKAP, Homer, and PSD-95 [16], [17], [25].
Localization (localized) of Shank1A in synapses
2) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0.19 Pain Relevance 0
Thus, the parallel changes in Shank1 upon manipulation of TRIM3 could be explained by decreased stabilization of Shank at the PSD secondary to GKAP loss.
Localization (manipulation) of Shank1 in Shank
3) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0 Pain Relevance 0

General Comments

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