INT303204

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.11
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Shank1) plasma membrane (Shank1) intracellular (Shank1)
protein complex assembly (Shank1) cytoplasm (Shank1)
Anatomy Link Frequency
Shank 1
head 1
Shank1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 8 83.24 Quite High
tetrodotoxin 16 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 8 58.56 Quite High
Disease 4 51.40 Quite High
Anxiety Disorder 4 30.48 Quite Low
Intellectual Impairment 4 27.12 Quite Low
Angelman Syndrome 4 24.32 Low Low
Autism 4 19.36 Low Low
Cognitive Disorder 4 8.00 Low Low
Attention Deficit Hyperactivity Disorder 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanism likely involves the direct or indirect loss of PSD scaffold proteins such as GKAP and Shank, as Shank1 strongly promotes spine head enlargement [25].
Negative_regulation (loss) of Shank in Shank
1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0 Pain Relevance 0
RBCC, and RING still resulted in loss of Shank1A protein in COS-7 cells, even though these mutants should be defective as E3 ligases and were incapable of suppressing GKAP protein expression (Figure 3D).
Negative_regulation (loss) of Shank1A protein
2) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0 Pain Relevance 0
Overexpression of TRIM3 in hippocampal neurons suppresses GKAP protein levels, concomitant with loss of Shank1 and reduced spine head width.
Negative_regulation (loss) of Shank1 in head
3) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0.11 Pain Relevance 0.04
In addition, proteasomal inhibition by MG-132 did not fully prevent the decrease in Shank1A induced by cotransfection of TRIM3 (data not shown).
Negative_regulation (decrease) of Shank1A
4) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox