INT303215

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.28
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Apc2) molecular_function (Apc2) cellular_component (Apc2)
biological_process (Apc2) cytoplasm (Apc2)
Apc2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 2 56.64 Quite High
tetrodotoxin 4 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Intellectual Impairment 1 94.04 High High
Syndrome 2 93.28 High High
Angelman Syndrome 1 92.64 High High
Disease 1 24.80 Low Low
Anxiety Disorder 1 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 1 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Autism 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The initial screen targeted cullins 1, 2, 3, 4A and 5, core subunits of a superfamily of multisubunit ubiquitin ligases [18]; APC2, a cullin-related subunit of the anaphase-promoting complex [19]; E6-AP (also known as Ube3A), a single subunit E3 whose mutation underlies a human mental retardation syndrome called Angelman syndrome [20]; and Mdm2, an E3 that was reported to ubiquitinate PSD-95 [21].
Regulation (targeted) of APC2 associated with intellectual impairment, syndrome and angelman syndrome
1) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0.28 Pain Relevance 0.03

General Comments

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