INT303233

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Context Info
Confidence 0.49
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.07
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Shank1) plasma membrane (Shank1) intracellular (Shank1)
protein complex assembly (Shank1) cytoplasm (Shank1)
Anatomy Link Frequency
dendrites 2
Shank1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 8 97.28 Very High Very High Very High
Glutamate receptor 4 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 2 72.32 Quite High
Syndrome 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Intellectual Impairment 2 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Autism 2 5.00 Very Low Very Low Very Low
Angelman Syndrome 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RBCC, and RING still resulted in loss of Shank1A protein in COS-7 cells, even though these mutants should be defective as E3 ligases and were incapable of suppressing GKAP protein expression (Figure 3D).
Negative_regulation (suppressing) of Gene_expression (expression) of GKAP protein
1) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0 Pain Relevance 0
-gal alone, suppressing activity with tetrodotoxin (TTX, 3 µM, 24 h) resulted in higher levels of GKAP staining in dendrites, whereas stimulating activity with bicuculline (50 µM, 24 h) reduced GKAP protein expression (Figure 4D, quantified in E).
Negative_regulation (reduced) of Gene_expression (expression) of GKAP protein in dendrites associated with tetrodotoxin
2) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0.07 Pain Relevance 0.10

General Comments

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