INT303245

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

plasma membrane (Dlgap1) molecular_function (Rnf123) cell-cell signaling (Dlgap1) ligase activity (Rnf123) biological_process (Rnf123) cytoplasm (Rnf123)

Rnf123 (Mus musculus) Dlgap1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat tetrodotoxin 4 5.00 Glutamate receptor 2 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Syndrome 2 5.00 Anxiety Disorder 1 5.00 Attention Deficit Hyperactivity Disorder 1 5.00 Intellectual Impairment 1 5.00 Cognitive Disorder 1 5.00 Disease 1 5.00 Autism 1 5.00 Angelman Syndrome 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Collectively, these data suggest that TRIM3 stimulates GKAP degradation by acting as a specific ubiquitin ligase for GKAP.

ubiquitin ligase Positive_regulation (stimulates) of Protein_catabolism (degradation) of GKAP

1) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0 Pain Relevance 0

General Comments

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