INT303287

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Context Info
Confidence 0.77
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 54
Disease Relevance 44.78
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Tardbp) RNA binding (Tardbp) nucleus (Tardbp)
DNA binding (Tardbp)
Anatomy Link Frequency
brains 16
neurons 2
nucleus 2
A11 2
muscle 1
Tardbp (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 51 92.36 High High
Eae 61 92.28 High High
Hippocampus 61 91.96 High High
Neuritis 51 79.92 Quite High
Pain 2 43.28 Quite Low
Spinal cord 7 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 4540 99.80 Very High Very High Very High
Targeted Disruption 395 99.28 Very High Very High Very High
Motor Neuron Diseases 368 98.12 Very High Very High Very High
Cognitive Disorder 166 97.32 Very High Very High Very High
Disease 271 96.44 Very High Very High Very High
Muscle Disease 20 95.48 Very High Very High Very High
Muscle Weakness 35 90.72 High High
Frontotemporal Lobar Degeneration 256 88.32 High High
Myocardial Infarction 2 86.68 High High
Parkinson's Disease 255 85.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that in NonTg mice, the levels of TDP-43 and TDP-35 were similar across the three different time points (Figure 2A-B).
Gene_expression (levels) of TDP-43
1) Confidence 0.77 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.81 Pain Relevance 0
Using Western blot analysis, we found that at 2 and 12 months of age, the levels of TDP-43 and TDP-35 were not statistically different between 3×Tg-AD and NonTg mice in the nuclear and cytosolic fractions (Figure 3A-C, G-I).
Gene_expression (levels) of TDP-43 associated with alzheimer's dementia
2) Confidence 0.77 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.64 Pain Relevance 0
We found that in NonTg mice, the levels of TDP-43 and TDP-35 were similar across the three different time points (Figure 2A-B).
Gene_expression (levels) of TDP-35
3) Confidence 0.77 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.82 Pain Relevance 0
As expected, the levels of TDP-43 and its C-terminal fragments were constantly higher in the nuclear fraction compared to the cytosolic fraction (Figure 3A, D, G).
Gene_expression (levels) of TDP-43
4) Confidence 0.77 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.62 Pain Relevance 0
Using Western blot analysis, we found that at 2 and 12 months of age, the levels of TDP-43 and TDP-35 were not statistically different between 3×Tg-AD and NonTg mice in the nuclear and cytosolic fractions (Figure 3A-C, G-I).
Gene_expression (levels) of TDP-35 associated with alzheimer's dementia
5) Confidence 0.77 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.64 Pain Relevance 0
In the nuclear fraction there were bands with different molecular weights, indicating more TDP-43 species.
Gene_expression (species) of TDP-43 in bands
6) Confidence 0.67 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.64 Pain Relevance 0
Specifically, in brains from AD patients, more often than not, tau immunoreactivity does not correlate with TDP-43 positive neurons [48], which is consistent with our data showing that TDP-43 and TDP-35 levels did not correlate with phosphorylated tau at Thr181.
Gene_expression (levels) of TDP-35 in neurons associated with alzheimer's dementia
7) Confidence 0.67 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.69 Pain Relevance 0
It is possible that a reduction in protein turnover may account for the higher levels of TDP-43 and TDP-35 in the 3×Tg-AD mice.
Gene_expression (levels) of TDP-43 associated with alzheimer's dementia
8) Confidence 0.67 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.47 Pain Relevance 0
It is possible that a reduction in protein turnover may account for the higher levels of TDP-43 and TDP-35 in the 3×Tg-AD mice.
Gene_expression (levels) of TDP-35 associated with alzheimer's dementia
9) Confidence 0.67 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.47 Pain Relevance 0
TDP-43 and TDP-35 levels were again similar between 3×Tg-AD and NonTg mice at 12 months of age (Figure 1E-F).
Gene_expression (levels) of TDP-35 associated with alzheimer's dementia
10) Confidence 0.67 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 1.14 Pain Relevance 0.06
TDP-43 and TDP-35 levels were again similar between 3×Tg-AD and NonTg mice at 12 months of age (Figure 1E-F).
Gene_expression (levels) of TDP-43 associated with alzheimer's dementia
11) Confidence 0.67 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 1.15 Pain Relevance 0.07
oligomers and TDP-43 levels led us to hypothesize that the buildup of A?
Gene_expression (levels) of TDP-43
12) Confidence 0.67 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.86 Pain Relevance 0
Notably, we found that TDP-43 and TDP-35 levels significantly correlated with A?
Gene_expression (levels) of TDP-43
13) Confidence 0.67 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.99 Pain Relevance 0
Notably, we found that TDP-43 and TDP-35 levels significantly correlated with A?
Gene_expression (levels) of TDP-35
14) Confidence 0.67 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.99 Pain Relevance 0
Neither was a correlation between AT270 and TDP-43 and TDP-35 levels observed at 12 months of age (Figure 4F-G; r2 = 0.4644, p = 0.14; and r2 = 0.4469, p = 0.15).
Gene_expression (levels) of TDP-35
15) Confidence 0.67 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.82 Pain Relevance 0.12
Specifically, in brains from AD patients, more often than not, tau immunoreactivity does not correlate with TDP-43 positive neurons [48], which is consistent with our data showing that TDP-43 and TDP-35 levels did not correlate with phosphorylated tau at Thr181.
Gene_expression (levels) of TDP-43 in neurons associated with alzheimer's dementia
16) Confidence 0.67 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.70 Pain Relevance 0
Taken together, these data indicate that the higher levels of TDP-43 and TDP-35 in the brains of 6-month-old 3×Tg-AD mice compared to NonTg mice are due to an increase of these proteins in the 3×Tg-AD mice as a function of age and not to a decrease of the levels of TDP-43 and TDP-35 in the brains of NonTg mice.
Gene_expression (levels) of TDP-35 in brains associated with alzheimer's dementia
17) Confidence 0.60 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.84 Pain Relevance 0
We also report that the levels of TDP-43 and its C-terminal fragment correlate with the levels of soluble A?
Gene_expression (levels) of TDP-43
18) Confidence 0.60 Published 2010 Journal Mol Neurodegener Section Abstract Doc Link PMC2989316 Disease Relevance 0.92 Pain Relevance 0
Unexpectedly, we found that the nuclear levels of TDP-43 and TDP-35 were not statistically different between NonTg and 3×Tg-AD mice (Figure 3D-F), suggesting that the increase of the levels in the cytosolic fraction is not simply due to a redistribution of TDP-43 from the nucleus into the cytoplasm.
Gene_expression (levels) of TDP-35 in nucleus associated with alzheimer's dementia
19) Confidence 0.60 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.56 Pain Relevance 0
This apparent discrepancy could arise from the sample preparation; indeed, the data presented here from the 3×Tg-AD mice where obtained from whole brain homogenize and compare the levels of soluble tau and soluble TDP-43 and TDP-35.
Gene_expression (levels) of TDP-43 in brain associated with alzheimer's dementia
20) Confidence 0.60 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2989316 Disease Relevance 0.81 Pain Relevance 0

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