INT303303

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Context Info
Confidence 0.49
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.97
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CHMP2B) endosome (CHMP2B) mitochondrion (CHMP2B)
nucleus (CHMP2B) intracellular (CHMP2B) cytoplasm (CHMP2B)
Anatomy Link Frequency
neurons 4
CHMP2B (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 7 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
carbamazepine 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Clonidine 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
Substantia nigra 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 7 99.32 Very High Very High Very High
Frontotemporal Dementia 5 94.92 High High
Motor Neuron Diseases 66 93.60 High High
Neurodegenerative Disease 24 93.20 High High
Bacterial Infection 1 83.32 Quite High
Cancer 5 82.36 Quite High
Neuroblastoma 1 72.52 Quite High
Dementia 16 70.40 Quite High
Disease 28 44.16 Quite Low
Multiple Sulfatase Deficiency Disease 5 34.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Depletion of ESCRT-III or overexpression of Vps2b mutant proteins in cortical neurons presents with a similar phenotype [52].
Positive_regulation (overexpression) of Gene_expression (overexpression) of Vps2b in neurons
1) Confidence 0.49 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.63 Pain Relevance 0
Additionally, there is strong evidence that CHMP2B mutations result in neuronal death; dendritic retraction and cell death seen in cortical neuron cultures transfected with CHMP2BIntron5 is a result of the failure of the aberrant protein to dissociate from the other subunits of the ESCRTIII prior to the next round of sorting, a step critical for the formation of MVBs [12].
Positive_regulation (transfected) of Gene_expression (transfected) of CHMP2BIntron5 in neuron associated with death
2) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0.34 Pain Relevance 0

General Comments

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