INT303306

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.09
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CHMP2B) endosome (CHMP2B) mitochondrion (CHMP2B)
nucleus (CHMP2B) intracellular (CHMP2B) cytoplasm (CHMP2B)
CHMP2B (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 4 95.20 Very High Very High Very High
cytokine 2 37.88 Quite Low
Kinase C 2 10.80 Low Low
Spinal cord 14 5.00 Very Low Very Low Very Low
medulla 8 5.00 Very Low Very Low Very Low
midbrain 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
backache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 8 86.84 High High
Motor Neuron Diseases 124 50.00 Quite Low
Stress 6 38.92 Quite Low
Dementia 30 26.72 Quite Low
Neuroblastoma 2 23.28 Low Low
Disease 26 19.36 Low Low
Repression 6 6.48 Low Low
Neurodegenerative Disease 16 5.00 Very Low Very Low Very Low
Spinal Muscular Atrophy 14 5.00 Very Low Very Low Very Low
Injury 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A second phenotype observed in the mutant cells was the presence of vacuoles with an accumulation of CHMP2B mutant protein on the outer membrane, termed halos (Figure 6E).
Positive_regulation (accumulation) of CHMP2B
1) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0 Pain Relevance 0.05
Induction of autophagy resulted in an increase in the number of vacuoles, providing further evidence that functional CHMP2B is required for the degradation of cytoplasmic components.
Positive_regulation (required) of CHMP2B
2) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0.09 Pain Relevance 0

General Comments

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