INT303308

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.85
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CHMP2B) endosome (CHMP2B) mitochondrion (CHMP2B)
nucleus (CHMP2B) intracellular (CHMP2B) cytoplasm (CHMP2B)
CHMP2B (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 14 26.56 Quite Low
medulla 8 25.92 Quite Low
midbrain 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
backache 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dementia 30 97.16 Very High Very High Very High
Spinal Muscular Atrophy 14 96.72 Very High Very High Very High
Injury 8 95.96 Very High Very High Very High
Motor Neuron Diseases 124 93.16 High High
Frontotemporal Dementia 4 60.04 Quite High
Frontotemporal Lobar Degeneration 2 42.16 Quite Low
Neurodegenerative Disease 16 38.40 Quite Low
Disease 26 37.76 Quite Low
Death 6 22.32 Low Low
Targeted Disruption 2 8.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Defects in CHMP2B were originally reported in a Danish pedigree with autosomal dominant FTD [4].
Negative_regulation (Defects) of CHMP2B associated with dementia
1) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0.37 Pain Relevance 0
While these features are not sufficiently distinctive to allow a morphological prediction of CHMP2B-related MND, our results indicate that a predominance of compact inclusions in a PMA case may warrant examination of the CHMP2B gene.
Negative_regulation (prediction) of CHMP2B associated with spinal muscular atrophy
2) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0.48 Pain Relevance 0

General Comments

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