INT303335

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.30
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Igfals, CHMP2B) endosome (CHMP2B) mitochondrion (CHMP2B)
intracellular (CHMP2B) cytoplasm (CHMP2B) cytosol (CHMP2B)
Anatomy Link Frequency
motor neuron 1
Igfals (Mus musculus)
CHMP2B (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 7 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 62 100.00 Very High Very High Very High
Disease 13 88.76 High High
Neurodegenerative Disease 8 63.00 Quite High
Dementia 15 61.52 Quite High
Spinal Muscular Atrophy 7 57.04 Quite High
Injury 4 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Fasciculation 4 5.00 Very Low Very Low Very Low
Respiratory Failure 3 5.00 Very Low Very Low Very Low
Repression 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We propose that CHMP2B missense mutations associate with ALS and demonstrate that these mutations give rise to a distinct clinical and neuropathological phenotype, cause a distinctive alteration in the motor neuron transcriptome and disrupt cellular pathology, compared to controls.


ALS Binding (associate) of CHMP2B in motor neuron associated with motor neuron diseases
1) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 1.30 Pain Relevance 0

General Comments

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