INT303343

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Context Info
Confidence 0.65
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.12
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Myh3)
Anatomy Link Frequency
muscle tissue 1
thick filaments 1
Myh3 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 10 74.04 Quite High
cytokine 5 58.24 Quite High
Spinal cord 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Sciatic nerve 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Muscular Atrophy 45 67.16 Quite High
Targeted Disruption 5 55.84 Quite High
Hypertrophy 5 41.12 Quite Low
Frailty 20 33.76 Quite Low
Appetite Loss 5 12.80 Low Low
Stress 5 11.60 Low Low
Pain 5 5.00 Very Low Very Low Very Low
Sprains And Strains 5 5.00 Very Low Very Low Very Low
Injury 5 5.00 Very Low Very Low Very Low
Nutritional Deficiencies 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We then separated the P and S myosin preparations on gel filtration columns and assessed the levels and distribution of MyHCemb and Ozz on immunoblots of the eluted fractions probed with anti MyHCemb, anti-Ozz and anti-MLC antibodies.
Gene_expression (antibodies) of MyHCemb
1) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844429 Disease Relevance 0 Pain Relevance 0
We showed that Ozz and Elo C are present together with sarcomeric myosin from the earliest stages of myofibrillogenesis, but we saw no obvious increase in Ozz/MyHCemb ratio in association with the onset of peak periods of MyHCemb degradation during embryogenesis (e.g.
Gene_expression (ratio) of MyHCemb
2) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844429 Disease Relevance 0 Pain Relevance 0
Immunofluorescence analyses of MyHCemb expression in muscle tissue were performed on hind limb muscles from wild-type and ozz?
Gene_expression (expression) of MyHCemb in muscle tissue
3) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844429 Disease Relevance 0 Pain Relevance 0.07
MyHCemb expression is associated with initiation of sarcomere formation [14], leading to the idea that it is optimized for self-assembly into new thick filaments followed by a sequence of subunit changes to give rise to adult myofilaments [15].
Gene_expression (expression) of MyHCemb in thick filaments
4) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844429 Disease Relevance 0.07 Pain Relevance 0.03
To test if expression of MyHCemb protein was also disturbed in the ozz?
Gene_expression (expression) of MyHCemb
5) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844429 Disease Relevance 0.06 Pain Relevance 0

General Comments

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