INT303347

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 4.06
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Jag1)
Anatomy Link Frequency
muscle 8
Notch 6
Jag1 (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 369 98.84 Very High Very High Very High
cytokine 5 96.92 Very High Very High Very High
Demyelination 9 28.64 Quite Low
imagery 10 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
intrathecal 6 5.00 Very Low Very Low Very Low
Spinal cord 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Sciatic nerve 5 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 378 98.84 Very High Very High Very High
Muscular Atrophy 45 98.68 Very High Very High Very High
Injury 5 93.84 High High
Frailty 20 90.24 High High
Disease 60 80.20 Quite High
Hypertrophy 5 62.48 Quite High
Appetite Loss 5 51.48 Quite High
Neurological Disease 6 22.84 Low Low
Stress 5 11.60 Low Low
Disorder Of Lipid Metabolism 27 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have shown earlier that the expression of ozz mRNA and Ozz protein increases during muscle development from embryonic day E12.5 onward [12] (Fig. 1A).
Positive_regulation (increases) of Gene_expression (expression) of ozz in muscle
1) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844429 Disease Relevance 0.64 Pain Relevance 0
Ozz expression was downregulated during the phase of degeneration, but was upregulated during the regeneration phase (Fig. 1C), confirming that Ozz expression is associated with muscle development and growth.


Positive_regulation (upregulated) of Gene_expression (expression) of Ozz in muscle
2) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844429 Disease Relevance 0.48 Pain Relevance 0
We showed that Ozz and Elo C are present together with sarcomeric myosin from the earliest stages of myofibrillogenesis, but we saw no obvious increase in Ozz/MyHCemb ratio in association with the onset of peak periods of MyHCemb degradation during embryogenesis (e.g.
Neg (no) Positive_regulation (increase) of Gene_expression (ratio) of Ozz
3) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844429 Disease Relevance 0 Pain Relevance 0
We have shown earlier that the expression of ozz mRNA and Ozz protein increases during muscle development from embryonic day E12.5 onward [12] (Fig. 1A).
Positive_regulation (increases) of Gene_expression (expression) of Ozz protein in muscle
4) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844429 Disease Relevance 0.64 Pain Relevance 0
Ozz expression is muscle-specific and upregulated during muscle fiber differentiation, but we show here that it is downregulated in muscle atrophy.
Positive_regulation (upregulated) of Gene_expression (expression) of Ozz in muscle associated with muscular atrophy
5) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844429 Disease Relevance 0.26 Pain Relevance 0.05
Jagged-1 has been found to be highly expressed in hypertrophic astrocytes within and around active MScl plaques lacking remyelination, while, in contrast, there was negligible jagged-1 expression in remyelinated lesions suggesting involvement of the Notch pathway in remyelination in MScl [21].
Positive_regulation (highly) of Gene_expression (expressed) of Jagged-1 in Notch associated with multiple sclerosis
6) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 0.68 Pain Relevance 0.24
Jagged-1 has been found to be highly expressed in hypertrophic astrocytes within and around active MScl plaques lacking remyelination, while, in contrast, there was negligible jagged-1 expression in remyelinated lesions suggesting involvement of the Notch pathway in remyelination in MScl [21].
Positive_regulation (was) of Gene_expression (expression) of jagged-1 in Notch associated with multiple sclerosis
7) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 0.68 Pain Relevance 0.24
Jagged-1 has been found to be highly expressed in hypertrophic astrocytes within and around active MScl plaques lacking remyelination, while, in contrast, there was negligible jagged-1 expression in remyelinated lesions suggesting involvement of the Notch pathway in remyelination in MScl [21].
Positive_regulation (negligible) of Gene_expression (expression) of jagged-1 in Notch associated with multiple sclerosis
8) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 0.68 Pain Relevance 0.24

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox