INT3034

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Context Info
Confidence 0.81
First Reported 1977
Last Reported 2011
Negated 0
Speculated 2
Reported most in Abstract
Documents 126
Total Number 128
Disease Relevance 50.81
Pain Relevance 72.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf) extracellular space (Ngf) aging (Ngf)
extracellular region (Ngf) molecular_function (Ngf)
Anatomy Link Frequency
nerve 21
neurons 5
mast cells 5
lactotrophs 4
macrophages 3
Ngf (Rattus norvegicus)
Ngf - R221W (2)
Pain Link Frequency Relevance Heat
Nerve growth factor 3938 100.00 Very High Very High Very High
Calcitonin gene-related peptide 375 100.00 Very High Very High Very High
cytokine 314 100.00 Very High Very High Very High
substance P 239 100.00 Very High Very High Very High
Serotonin 97 100.00 Very High Very High Very High
5HT 20 100.00 Very High Very High Very High
algogenic 18 100.00 Very High Very High Very High
mu opioid receptor 8 100.00 Very High Very High Very High
bradykinin 59 99.90 Very High Very High Very High
Dorsal horn 128 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 74 100.00 Very High Very High Very High
Asthma 24 100.00 Very High Very High Very High
Nervous System Injury 444 99.98 Very High Very High Very High
Brain Injury 49 99.92 Very High Very High Very High
Ataxia 8 99.92 Very High Very High Very High
INFLAMMATION 696 99.74 Very High Very High Very High
Injury 1265 99.68 Very High Very High Very High
Ganglion Cysts 314 99.56 Very High Very High Very High
Polycystic Ovary Syndrome 137 99.56 Very High Very High Very High
Disease 162 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies have demonstrated that nerve growth factor (NGF) is released in incised tissue and contributes to hyperalgesia in incisional pain.
Localization (released) of NGF in nerve associated with pain, hyperalgesia and nerve growth factor
1) Confidence 0.81 Published 2007 Journal Anesthesiology Section Abstract Doc Link 17585224 Disease Relevance 0.38 Pain Relevance 0.57
Previous studies have demonstrated that nerve growth factor (NGF) is released in incised tissue and contributes to hyperalgesia in incisional pain.
Localization (released) of nerve growth factor in nerve associated with pain, hyperalgesia and nerve growth factor
2) Confidence 0.81 Published 2007 Journal Anesthesiology Section Abstract Doc Link 17585224 Disease Relevance 0.39 Pain Relevance 0.57
In this study, baby hamster kidney cells (BHK) genetically modified to secrete human NGF (hNGF) were encapsulated in semipermeable membranes and implanted intraventricularly.
Localization (secrete) of NGF in kidney
3) Confidence 0.81 Published 1996 Journal Cell Transplant Section Abstract Doc Link 8689032 Disease Relevance 0.18 Pain Relevance 0.14
A final result showed that endogenous release of NGF in a model of acute inflammation (complete Freund's adjuvant-induced inflammation) may be involved in the development of thermal hyperalgesia, since it could be blocked by concomitant treatment with anti-NGF antisera.
Localization (release) of NGF associated with inflammation, nerve growth factor and thermal hyperalgesia
4) Confidence 0.80 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 7704300 Disease Relevance 1.27 Pain Relevance 1.76
Local release of NGF from engineered T cells was demonstrable by immunocytochemistry and by an anti-inflammatory effect on infiltrating macrophages.
Localization (release) of NGF in macrophages associated with inflammation and nerve growth factor
5) Confidence 0.80 Published 1995 Journal Nat. Med. Section Abstract Doc Link 7584988 Disease Relevance 0.17 Pain Relevance 0.36
Astrocytes and oligodendrocytes can be induced to secrete NGF and NT-3 [13,14], and these cells are the most likely the source of NGF and NT-3 in CSF.
Localization (secrete) of NGF in oligodendrocytes associated with nerve growth factor
6) Confidence 0.80 Published 2001 Journal BMC Pediatr Section Body Doc Link PMC57003 Disease Relevance 0.62 Pain Relevance 0.77
From the sustained release experiment, NAT-NGF was found to be quickly released at the first day, whereas LBD-NGF could gradually release from laminin during 6 days.
Localization (release) of NAT-NGF associated with nerve growth factor
7) Confidence 0.80 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2703785 Disease Relevance 0.14 Pain Relevance 0.66
Moreover, the expression of this nociceptive response seems to depend on the synergic activity of NGF and sympathetic amines released during TMJ inflammation acting on beta2-adrenergic receptors.


Localization (released) of NGF in sympathetic
8) Confidence 0.80 Published 2008 Journal Life Sci. Section Body Doc Link 18930742 Disease Relevance 0 Pain Relevance 0
We provide evidence that nerve growth factor (NGF), a secreted regulatory protein that controls neuronal survival during development, is a key mediator of pain and weight loss in auto-immune arthritis.
Localization (secreted) of NGF in neuronal associated with pain, weight loss, nerve growth factor and arthritis
9) Confidence 0.80 Published 2005 Journal Pain Section Abstract Doc Link 15927377 Disease Relevance 1.30 Pain Relevance 0.82
We provide evidence that nerve growth factor (NGF), a secreted regulatory protein that controls neuronal survival during development, is a key mediator of pain and weight loss in auto-immune arthritis.
Localization (secreted) of nerve growth factor in neuronal associated with pain, weight loss, nerve growth factor and arthritis
10) Confidence 0.80 Published 2005 Journal Pain Section Abstract Doc Link 15927377 Disease Relevance 1.30 Pain Relevance 0.83
The reduction in numbers of sensory fibers observed in the patients is therefore probably due to loss of trophic support as a result of drastically reduced secretion of NGF from the target organs.
Localization (secretion) of NGF
11) Confidence 0.79 Published 2009 Journal Neurobiol. Dis. Section Abstract Doc Link 19038341 Disease Relevance 0.21 Pain Relevance 0.25
Nerve growth factor (NGF) is synthesized by and released from ovarian cells and the presence of NGF receptors on nerve fibres innervating the ovary suggests that NGF is one of the target-derived neurotrophins involved in the development and maintenance of ovarian innervation [12].
Localization (released) of Nerve growth factor in nerve associated with nerve growth factor
12) Confidence 0.79 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC155675 Disease Relevance 0.91 Pain Relevance 0.40
Nerve growth factor (NGF) is synthesized by and released from ovarian cells and the presence of NGF receptors on nerve fibres innervating the ovary suggests that NGF is one of the target-derived neurotrophins involved in the development and maintenance of ovarian innervation [12].
Localization (released) of NGF in nerve associated with nerve growth factor
13) Confidence 0.79 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC155675 Disease Relevance 0.90 Pain Relevance 0.40
In the periphery, NGF is released in response to inflammation and subsequently acts on its high-affinity receptor, TrkA, expressed on a subset of nociceptive dorsal root ganglion (DRG) neurons, resulting in hyperalgesia [19].
Localization (released) of NGF in neurons associated with ganglion cysts, nociception, dorsal root ganglion, hyperalgesia, inflammation and nerve growth factor
14) Confidence 0.79 Published 2011 Journal Mol Pain Section Body Doc Link PMC3022746 Disease Relevance 1.34 Pain Relevance 1.39
Nerve growth factor (NGF) is secreted by tissues and promotes the expression of ion channels and neuropeptides in sensory neurons involved in pain transmission.
Localization (secreted) of NGF in Nerve associated with pain, nerve growth factor and neuropeptide
15) Confidence 0.79 Published 2006 Journal J Hand Surg Br Section Abstract Doc Link 16928414 Disease Relevance 0.71 Pain Relevance 0.98
Nerve growth factor (NGF) is secreted by tissues and promotes the expression of ion channels and neuropeptides in sensory neurons involved in pain transmission.
Localization (secreted) of Nerve growth factor in Nerve associated with pain, nerve growth factor and neuropeptide
16) Confidence 0.79 Published 2006 Journal J Hand Surg Br Section Abstract Doc Link 16928414 Disease Relevance 0.71 Pain Relevance 0.98
The activity-dependent release of NGF did not depend on extracellular Ca2+, but was sensitive to the intracellular Ca2+ chelator bis-(o-aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid tetra(acetoxymethyl)-ester, and to depletion of intracellular calcium stores.
Localization (release) of NGF associated with nerve growth factor
17) Confidence 0.77 Published 1995 Journal Eur. J. Neurosci. Section Abstract Doc Link 7582095 Disease Relevance 0 Pain Relevance 0.96
The KCl- and veratridine-initiated NGF release was suppressed by tetrodotoxin; release by glutamate was less sensitive to tetrodotoxin but was sodium-dependent.
Localization (release) of NGF associated with tetrodotoxin, glutamate and nerve growth factor
18) Confidence 0.77 Published 1995 Journal Eur. J. Neurosci. Section Abstract Doc Link 7582095 Disease Relevance 0 Pain Relevance 0.87
In both systems there was activity-dependent NGF release initiated by high potassium (KCl), veratridine, glutamate or carbachol.
Localization (release) of NGF associated with glutamate and nerve growth factor
19) Confidence 0.77 Published 1995 Journal Eur. J. Neurosci. Section Abstract Doc Link 7582095 Disease Relevance 0 Pain Relevance 0.80
The combination of both treatments reduced NGF release to below the detection limit, suggesting that basal release has constitutive and regulated components, the latter presumably resulting from spontaneous activity of interconnected neurons.
Localization (release) of NGF in neurons associated with nerve growth factor
20) Confidence 0.77 Published 1995 Journal Eur. J. Neurosci. Section Abstract Doc Link 7582095 Disease Relevance 0 Pain Relevance 0.77

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