INT303482

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Context Info
Confidence 0.20
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.27
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE5A) signal transduction (PDE5A) cellular_component (PDE5A)
PDE5A (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 3 95.52 Very High Very High Very High
cva 18 50.00 Quite Low
antagonist 5 41.40 Quite Low
nud 2 12.40 Low Low
Inflammation 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
fluoxetine 1 5.00 Very Low Very Low Very Low
Duloxetine 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 37 99.60 Very High Very High Very High
Rhinitis 1 97.16 Very High Very High Very High
Anaemia 1 96.32 Very High Very High Very High
Headache 3 95.52 Very High Very High Very High
Increased Venous Pressure Under Development 3 94.80 High High
Heart Rate Under Development 1 94.20 High High
Pressure And Volume Under Development 2 93.32 High High
Acute Liver Failure 1 92.32 High High
Congenital Anomalies 1 90.92 High High
Hypersensitivity 3 81.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphodiesterase 5 inhibitors PH is associated with upregulation of vascular PDE5, which rapidly degrades cGMP, leading to reduced levels of nitric oxide, a potent vasodilator.
Positive_regulation (upregulation) of Protein_catabolism (degrades) of PDE5 associated with pulmonary hypertension
1) Confidence 0.20 Published 2010 Journal Curr Treat Options Cardiovasc Med Section Body Doc Link PMC2844955 Disease Relevance 1.27 Pain Relevance 0.10

General Comments

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