INT303483

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.50
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE5A) signal transduction (PDE5A) cellular_component (PDE5A)
PDE5A (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 8 95.92 Very High Very High Very High
alcohol 1 83.58 Quite High
cva 21 50.00 Quite Low
antagonist 5 41.40 Quite Low
nud 6 10.48 Low Low
Inflammation 4 5.00 Very Low Very Low Very Low
backache 4 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
fluoxetine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 37 99.60 Very High Very High Very High
Rhinitis 1 97.16 Very High Very High Very High
Anaemia 1 96.32 Very High Very High Very High
Headache 8 95.92 Very High Very High Very High
Increased Venous Pressure Under Development 9 94.80 High High
Heart Rate Under Development 1 94.20 High High
Pressure And Volume Under Development 2 93.32 High High
Acute Liver Failure 1 92.32 High High
Congenital Anomalies 2 90.92 High High
Hypersensitivity 3 81.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tadalafil was approved for use in the United States in November 2003, after both sildenafil and vardenafil were approved.11 Tadalafil differs from the other 2 PDE5Is in that the absorption does not appear to be influenced by the intake of fatty meals or alcohol.11 Peak serum concentration is attained about 2 hours postdose rather than 1 hour as occurs with the other 2 PDE5Is.12 Tadalafil is also unique in that it has a long elimination half-life of approximately 18 hours.13 The potential advantage of this prolonged duration of action is that the other medications can be separated temporally from sexual activity.14 The theoretical impact of this pharmacokinetic property is that sexual spontaneity may be more easily restored using this medication.15 However, the prolonged half-life of tadalafil also makes it more prone to long-lasting adverse effects (such as headache) relative to the other PDE5Is, with up to 30% of men on tadalafil treatment reporting side effects lasting greater than 12 hours.16 Importantly, chronic dosing of tadalafil has not been shown to lead to upregulation of PDE5 in human penile tissue,17 an effect that has been observed in rat penile tissue exposed continuously to high doses of sildenafil.18 This difference may theoretically make tadalafil less likely than sildenafil to lose its efficacy over time due to tachyphylaxis.
Positive_regulation (upregulation) of PDE5 associated with headache and alcohol
1) Confidence 0.39 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2939761 Disease Relevance 0.23 Pain Relevance 0.14
Phosphodiesterase 5 inhibitors PH is associated with upregulation of vascular PDE5, which rapidly degrades cGMP, leading to reduced levels of nitric oxide, a potent vasodilator.
Positive_regulation (upregulation) of PDE5 associated with pulmonary hypertension
2) Confidence 0.27 Published 2010 Journal Curr Treat Options Cardiovasc Med Section Body Doc Link PMC2844955 Disease Relevance 1.27 Pain Relevance 0.10

General Comments

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