INT303488

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Context Info
Confidence 0.18
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.96
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp1a2) endoplasmic reticulum (Cyp1a2) enzyme binding (Cyp1a2)
Anatomy Link Frequency
platelet 2
Cyp1a2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1 18.20 Low Low
adenocard 2 5.00 Very Low Very Low Very Low
beta blocker 1 5.00 Very Low Very Low Very Low
Nicotine 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 64 100.00 Very High Very High Very High
Emergencies 3 99.26 Very High Very High Very High
Myocardial Infarction 27 81.76 Quite High
Diabetes Mellitus 6 80.24 Quite High
Coronary Artery Disease 5 52.84 Quite High
Thrombosis 2 51.84 Quite High
Acute Coronary Syndrome 1 46.48 Quite Low
Chronic Renal Failure 2 41.76 Quite Low
Hypertension 4 18.24 Low Low
INFLAMMATION 1 18.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The polymorphism of this subtype can induce loss-of-function to a considerable extent.25)26) Because CYP1A2 affects only the first oxidative step of clopidogrel, induction of CYP1A2 by smoking may have a relatively weak impact on clopidogrel activation.25)26) Furthermore, we assessed residual platelet reactivity at least 3 days after emergency stenting, which may be related to a decrease in smoking-induced CYP1A2 activity.
Negative_regulation (decrease) of Positive_regulation (induced) of CYP1A2 in platelet associated with emergencies and nicotine addiction
1) Confidence 0.18 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2844977 Disease Relevance 0.96 Pain Relevance 0

General Comments

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