INT303538

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Context Info
Confidence 0.65
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.92
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Fgfr1) nucleus (Fgfr1) kinase activity (Fgfr1)
cytoplasm (Fgfr1)
Anatomy Link Frequency
hair follicle 1
second branchial arch 1
Fgfr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 16 66.40 Quite High
Inflammation 26 44.00 Quite Low
Inflammatory response 5 31.80 Quite Low
cytokine 9 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
member 8 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
sodium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 18 92.40 High High
Alopecia 3 91.04 High High
Syndrome 2 83.28 Quite High
Craniosynostosis 1 82.88 Quite High
Skin Abnormalities 2 73.72 Quite High
Obesity 17 71.52 Quite High
Targeted Disruption 78 67.36 Quite High
Aging 5 63.20 Quite High
Sprains And Strains 2 62.00 Quite High
Gallstones 1 56.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It seems likely that FGF7 together with FGF10 and FGF22 cooperatively orchestrate hair regeneration via activation of FGFR1IIIb and FGFR2IIIb on hair follicle keratinocytes.
Positive_regulation (activation) of FGFR1IIIb in hair follicle
1) Confidence 0.65 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.16 Pain Relevance 0
A hypomorphic allele of Fgfr1 has been used to demonstrate that FGFR1 is required for NCC migration into the second branchial arch [8].
Positive_regulation (required) of FGFR1 in second branchial arch
2) Confidence 0.44 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.26 Pain Relevance 0
Klotho most efficiently binds to and activates Fgfr1c among several isoforms of Fgfrs in cultured cells (Urakawa et al. 2006).
Positive_regulation (activates) of Fgfr1c
3) Confidence 0.22 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.49 Pain Relevance 0.03

General Comments

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