INT303539

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.96
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Fgfr1) nucleus (Fgfr1) kinase activity (Fgfr1)
cytoplasm (Fgfr1)
Anatomy Link Frequency
astrocytes 1
Fgfr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 50 87.84 High High
Bile 16 77.36 Quite High
Central nervous system 11 76.48 Quite High
Inflammatory response 5 65.20 Quite High
Inflammation 26 5.00 Very Low Very Low Very Low
medulla 15 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
member 8 2 5.00 Very Low Very Low Very Low
Peripheral nervous system 2 5.00 Very Low Very Low Very Low
Spinal nerve ligature 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Abnormalities 2 90.72 High High
Spinal Cord Injury 12 87.84 High High
Obesity 17 82.48 Quite High
Targeted Disruption 52 73.44 Quite High
Psoriasis 7 67.72 Quite High
Gallstones 1 67.68 Quite High
INFLAMMATION 29 64.84 Quite High
Aging 5 57.84 Quite High
Sprains And Strains 1 56.64 Quite High
Alopecia 3 55.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it binds a different set of FGFs than FGFR1IIIb and FGFR2IIIb (Zhang et al., 2006), which suggests distinct functions.
FGFR1IIIb Binding (binds) of
1) Confidence 0.45 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.28 Pain Relevance 0.03
These results indicate that Fgf23 activates Fgfr1c, which forms a complex with ?
Fgfr1c Binding (forms) of
2) Confidence 0.17 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.59 Pain Relevance 0.04
Alternatively, this may be due to FGF-2 release from injured cells into the extracellular matrix (D'Amore, 1990), followed by binding to FGFR1-bearing astrocytes.
FGFR1-bearing Binding (binding) of in astrocytes
3) Confidence 0.01 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.09 Pain Relevance 0.13

General Comments

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