INT303543

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 3.28
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1f8) extracellular region (Il1f8) molecular_function (Il1f8)
biological_process (Il1f8)
Anatomy Link Frequency
keratinocytes 3
epidermis 1
T cells 1
Il1f8 (Mus musculus)
Pain Link Frequency Relevance Heat
member 8 16 100.00 Very High Very High Very High
cytokine 64 97.52 Very High Very High Very High
Inflammation 208 95.84 Very High Very High Very High
Inflammatory response 40 95.76 Very High Very High Very High
Inflammatory mediators 8 80.64 Quite High
Inflammatory stimuli 8 73.04 Quite High
psoriasis 8 11.60 Low Low
fibrosis 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Psoriasis 56 97.56 Very High Very High Very High
Targeted Disruption 112 97.12 Very High Very High Very High
Skin Diseases 40 96.36 Very High Very High Very High
INFLAMMATION 232 95.84 Very High Very High Very High
Acanthosis 64 88.36 High High
Dermatitis 48 75.96 Quite High
Injury 24 75.32 Quite High
Aging 32 75.08 Quite High
Adhesions 8 71.28 Quite High
Skin Abnormalities 16 69.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The first possibility seems unlikely because expression levels of S100A8/A9 and IL-1F8 were similar in cultured keratinocytes from mice of both genotypes.
Gene_expression (expression) of IL-1F8 in keratinocytes
1) Confidence 0.42 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.59 Pain Relevance 0.28
Using RNAs from the purified cell populations, we found that S100A8/A9 are mainly produced by keratinocytes and up-regulated in this cell type in K5-R1/R2 mice, whereas IL-1F8 was predominantly expressed by ??
Gene_expression (expressed) of IL-1F8 in keratinocytes
2) Confidence 0.42 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.26 Pain Relevance 0.12
Preliminary results also showed that intradermal injection of IL-1F8 induces expression of the same growth factors in vivo.
Gene_expression (injection) of IL-1F8
3) Confidence 0.36 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.83 Pain Relevance 0.25
Intradermal injection of IL-1F8
Gene_expression (injection) of IL-1F8
4) Confidence 0.36 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0 Pain Relevance 0
Concomitantly, expression of IL-1F8 was reduced by 30%, whereas no obvious change in the expression of claudin 1, claudin 3, or occludin was observed (unpublished data).
Gene_expression (expression) of IL-1F8
5) Confidence 0.33 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.15 Pain Relevance 0.04
T cells, which produce interleukin-1 family member 8 and S100A8/A9 proteins.
Gene_expression (produce) of interleukin-1 family member 8 in T cells associated with member 8
6) Confidence 0.33 Published 2010 Journal The Journal of Cell Biology Section Abstract Doc Link PMC2845079 Disease Relevance 0.62 Pain Relevance 0.29
T cell–derived IL-1F8, keratinocyte-derived S100A8 and A9, and several keratinocyte mitogens produced by dermal cells (summarized in Fig. 10 C).


Gene_expression (produced) of IL-1F8 in keratinocyte
7) Confidence 0.33 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.19 Pain Relevance 0.05
We found a strongly increased expression of the genes encoding S100A8, S100A9, and IL-1F8 in the epidermis of K5-R1/R2 mice, whereas TNF and IL-1?
Gene_expression (expression) of IL-1F8 in epidermis
8) Confidence 0.14 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.63 Pain Relevance 0.41

General Comments

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